Substrate-dependent modulation of the leukotriene A(4) hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation

The aminopeptidase activity (AP) of the leukotriene A(4) hydrolase (LTA(4)H) enzyme has emerged as a therapeutic target to modulate host immunity. Initial reports focused on the benefits of augmenting the LTA(4)H AP activity and clearing its putative pro-inflammatory substrate Pro-Gly-Pro (PGP). How...

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Detalles Bibliográficos
Autores principales: Lee, Kyung Hyeon, Ali, Nadia Fazal, Lee, Soo Hyeon, Zhang, Zhimin, Burdick, Marie, Beaulac, Zachary J., Petruncio, Greg, Li, Linxia, Xiang, Jiangdong, Chung, Ezra M., Foreman, Kenneth W., Noble, Schroeder M., Shim, Yun M., Paige, Mikell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177663/
https://www.ncbi.nlm.nih.gov/pubmed/35676292
http://dx.doi.org/10.1038/s41598-022-13238-6

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