Cargando…
Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea
Impaired glucose metabolism reflects neuronal/synaptic dysfunction and cognitive function decline in patients with obstructive sleep apnea (OSA). The study investigated the extent to which exercise training (ET) improves cerebral metabolic glucose rate (CMRgl) and cognitive function in patients with...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177702/ https://www.ncbi.nlm.nih.gov/pubmed/35676287 http://dx.doi.org/10.1038/s41598-022-13115-2 |
_version_ | 1784722923432443904 |
---|---|
author | Ueno-Pardi, Linda M. Souza-Duran, Fabio L. Matheus, Larissa Rodrigues, Amanda G. Barbosa, Eline R. F. Cunha, Paulo J. Carneiro, Camila G. Costa, Naomi A. Ono, Carla R. Buchpiguel, Carlos A. Negrão, Carlos E. Lorenzi-Filho, Geraldo Busatto-Filho, Geraldo |
author_facet | Ueno-Pardi, Linda M. Souza-Duran, Fabio L. Matheus, Larissa Rodrigues, Amanda G. Barbosa, Eline R. F. Cunha, Paulo J. Carneiro, Camila G. Costa, Naomi A. Ono, Carla R. Buchpiguel, Carlos A. Negrão, Carlos E. Lorenzi-Filho, Geraldo Busatto-Filho, Geraldo |
author_sort | Ueno-Pardi, Linda M. |
collection | PubMed |
description | Impaired glucose metabolism reflects neuronal/synaptic dysfunction and cognitive function decline in patients with obstructive sleep apnea (OSA). The study investigated the extent to which exercise training (ET) improves cerebral metabolic glucose rate (CMRgl) and cognitive function in patients with OSA. Patients with moderate to severe OSA were randomly assigned to ET (3 times/week, n = 23) or no intervention (control, n = 24). Echocardiography and apolipoprotein ε4 (APOEε4) genotyping were obtained at baseline. Both groups underwent cardiopulmonary exercise testing, polysomnography, cognitive tests, brain magnetic resonance imaging, and (18)F-fluoro-2-deoxy-d-Glucose positron emission tomography ((18)FDG-PET) at baseline and study end. Compared with control, exercise-trained group had improved exercise capacity, decreased apnea–hypopnea index (AHI), oxygen desaturation and arousal index; increased attention/executive functioning, increased CMRgl in the right frontal lobe (P < 0.05). After ET an inverse relationships occurred between CMRgl and obstructive AHI (r = − 0.43, P < 0.05) and apnea arousal index (r = − 0.53, P < 0.05), and between the changes in CMRgl and changes in mean O(2) saturation during sleep and non-rapid eye movement sleep (r = − 0.43, P < 0.05), desaturation during arousal (r = − 0.44, P < 0.05), and time to attention function testing (r = − 0.46, P < 0.05). ET improves OSA severity and CMRg in the frontal lobe, which helps explain the improvement in attention/executive functioning. Our study provides promising data that reinforce the growing idea that ET may be a valuable tool to prevent hypoxia associated with decreased brain metabolism and cognitive functioning in patients with moderate to severe OSA. Trial registration: NCT02289625 (13/11/2014). |
format | Online Article Text |
id | pubmed-9177702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91777022022-06-10 Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea Ueno-Pardi, Linda M. Souza-Duran, Fabio L. Matheus, Larissa Rodrigues, Amanda G. Barbosa, Eline R. F. Cunha, Paulo J. Carneiro, Camila G. Costa, Naomi A. Ono, Carla R. Buchpiguel, Carlos A. Negrão, Carlos E. Lorenzi-Filho, Geraldo Busatto-Filho, Geraldo Sci Rep Article Impaired glucose metabolism reflects neuronal/synaptic dysfunction and cognitive function decline in patients with obstructive sleep apnea (OSA). The study investigated the extent to which exercise training (ET) improves cerebral metabolic glucose rate (CMRgl) and cognitive function in patients with OSA. Patients with moderate to severe OSA were randomly assigned to ET (3 times/week, n = 23) or no intervention (control, n = 24). Echocardiography and apolipoprotein ε4 (APOEε4) genotyping were obtained at baseline. Both groups underwent cardiopulmonary exercise testing, polysomnography, cognitive tests, brain magnetic resonance imaging, and (18)F-fluoro-2-deoxy-d-Glucose positron emission tomography ((18)FDG-PET) at baseline and study end. Compared with control, exercise-trained group had improved exercise capacity, decreased apnea–hypopnea index (AHI), oxygen desaturation and arousal index; increased attention/executive functioning, increased CMRgl in the right frontal lobe (P < 0.05). After ET an inverse relationships occurred between CMRgl and obstructive AHI (r = − 0.43, P < 0.05) and apnea arousal index (r = − 0.53, P < 0.05), and between the changes in CMRgl and changes in mean O(2) saturation during sleep and non-rapid eye movement sleep (r = − 0.43, P < 0.05), desaturation during arousal (r = − 0.44, P < 0.05), and time to attention function testing (r = − 0.46, P < 0.05). ET improves OSA severity and CMRg in the frontal lobe, which helps explain the improvement in attention/executive functioning. Our study provides promising data that reinforce the growing idea that ET may be a valuable tool to prevent hypoxia associated with decreased brain metabolism and cognitive functioning in patients with moderate to severe OSA. Trial registration: NCT02289625 (13/11/2014). Nature Publishing Group UK 2022-06-08 /pmc/articles/PMC9177702/ /pubmed/35676287 http://dx.doi.org/10.1038/s41598-022-13115-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Ueno-Pardi, Linda M. Souza-Duran, Fabio L. Matheus, Larissa Rodrigues, Amanda G. Barbosa, Eline R. F. Cunha, Paulo J. Carneiro, Camila G. Costa, Naomi A. Ono, Carla R. Buchpiguel, Carlos A. Negrão, Carlos E. Lorenzi-Filho, Geraldo Busatto-Filho, Geraldo Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea |
title | Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea |
title_full | Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea |
title_fullStr | Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea |
title_full_unstemmed | Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea |
title_short | Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea |
title_sort | effects of exercise training on brain metabolism and cognitive functioning in sleep apnea |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177702/ https://www.ncbi.nlm.nih.gov/pubmed/35676287 http://dx.doi.org/10.1038/s41598-022-13115-2 |
work_keys_str_mv | AT uenopardilindam effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT souzaduranfabiol effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT matheuslarissa effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT rodriguesamandag effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT barbosaelinerf effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT cunhapauloj effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT carneirocamilag effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT costanaomia effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT onocarlar effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT buchpiguelcarlosa effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT negraocarlose effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT lorenzifilhogeraldo effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea AT busattofilhogeraldo effectsofexercisetrainingonbrainmetabolismandcognitivefunctioninginsleepapnea |