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Assessment of long‐term outcomes post living liver donation highlights the importance of scientific integrity when presenting transplant registry data
Living donor liver transplantation has expanded in recent years, particularly in North America. As experience with this procedure has matured over the last 25 years, centers are increasingly faced with potential living donors who are more medically complex. As donors move through the evaluation proc...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177716/ https://www.ncbi.nlm.nih.gov/pubmed/35352461 http://dx.doi.org/10.1111/ajt.17045 |
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author | Emamaullee, Juliet Heimbach, Julie K. Olthoff, Kim M. Pomfret, Elizabeth A. Roberts, John P. Selzner, Nazia Taner, T. Melcher, M. DiSabato, D. Pomfret, E. Jackson, W. Han, H. Montenovo, M. |
author_facet | Emamaullee, Juliet Heimbach, Julie K. Olthoff, Kim M. Pomfret, Elizabeth A. Roberts, John P. Selzner, Nazia Taner, T. Melcher, M. DiSabato, D. Pomfret, E. Jackson, W. Han, H. Montenovo, M. |
author_sort | Emamaullee, Juliet |
collection | PubMed |
description | Living donor liver transplantation has expanded in recent years, particularly in North America. As experience with this procedure has matured over the last 25 years, centers are increasingly faced with potential living donors who are more medically complex. As donors move through the evaluation process, completing the informed consent process continues to be challenged by a paucity of granular data demonstrating long‐term outcomes and overall safety specifically in the otherwise “healthy” living liver donor population. Two recently published studies examined long‐term outcomes post‐living liver donation using Korean registry data and reported similar results, with excellent overall survival when compared to appropriately matched controls. However, the authors of these studies were presented differently, with one reporting an alarmist view based on one aspect of a suboptimal analysis approach using an inappropriate comparator group. Herein, the North American Living Liver Donor Innovation Group (NALLDIG) consortium discusses these two studies and their potential impact on living liver donation in North America, ultimately highlighting the importance of scientific integrity in data presentation and dissemination when using transplant registry data. |
format | Online Article Text |
id | pubmed-9177716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91777162022-10-14 Assessment of long‐term outcomes post living liver donation highlights the importance of scientific integrity when presenting transplant registry data Emamaullee, Juliet Heimbach, Julie K. Olthoff, Kim M. Pomfret, Elizabeth A. Roberts, John P. Selzner, Nazia Taner, T. Melcher, M. DiSabato, D. Pomfret, E. Jackson, W. Han, H. Montenovo, M. Am J Transplant Personal Viewpoints Living donor liver transplantation has expanded in recent years, particularly in North America. As experience with this procedure has matured over the last 25 years, centers are increasingly faced with potential living donors who are more medically complex. As donors move through the evaluation process, completing the informed consent process continues to be challenged by a paucity of granular data demonstrating long‐term outcomes and overall safety specifically in the otherwise “healthy” living liver donor population. Two recently published studies examined long‐term outcomes post‐living liver donation using Korean registry data and reported similar results, with excellent overall survival when compared to appropriately matched controls. However, the authors of these studies were presented differently, with one reporting an alarmist view based on one aspect of a suboptimal analysis approach using an inappropriate comparator group. Herein, the North American Living Liver Donor Innovation Group (NALLDIG) consortium discusses these two studies and their potential impact on living liver donation in North America, ultimately highlighting the importance of scientific integrity in data presentation and dissemination when using transplant registry data. John Wiley and Sons Inc. 2022-04-06 2022-06 /pmc/articles/PMC9177716/ /pubmed/35352461 http://dx.doi.org/10.1111/ajt.17045 Text en © 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Personal Viewpoints Emamaullee, Juliet Heimbach, Julie K. Olthoff, Kim M. Pomfret, Elizabeth A. Roberts, John P. Selzner, Nazia Taner, T. Melcher, M. DiSabato, D. Pomfret, E. Jackson, W. Han, H. Montenovo, M. Assessment of long‐term outcomes post living liver donation highlights the importance of scientific integrity when presenting transplant registry data |
title | Assessment of long‐term outcomes post living liver donation highlights the importance of scientific integrity when presenting transplant registry data |
title_full | Assessment of long‐term outcomes post living liver donation highlights the importance of scientific integrity when presenting transplant registry data |
title_fullStr | Assessment of long‐term outcomes post living liver donation highlights the importance of scientific integrity when presenting transplant registry data |
title_full_unstemmed | Assessment of long‐term outcomes post living liver donation highlights the importance of scientific integrity when presenting transplant registry data |
title_short | Assessment of long‐term outcomes post living liver donation highlights the importance of scientific integrity when presenting transplant registry data |
title_sort | assessment of long‐term outcomes post living liver donation highlights the importance of scientific integrity when presenting transplant registry data |
topic | Personal Viewpoints |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177716/ https://www.ncbi.nlm.nih.gov/pubmed/35352461 http://dx.doi.org/10.1111/ajt.17045 |
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