Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts

Despite several advances in the field, pharmacodynamic outcome measures reflective of LRRK2 kinase activity in clinical biofluids remain urgently needed. A variety of targets and approaches have been utilized including assessments of LRRK2 itself (levels, phosphorylation), or its substrates (e.g. Ra...

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Detalles Bibliográficos
Autores principales: Petropoulou-Vathi, Lilian, Simitsi, Athina, Valkimadi, Politymi-Eleni, Kedariti, Maria, Dimitrakopoulos, Lampros, Koros, Christos, Papadimitriou, Dimitra, Papadimitriou, Alexandros, Stefanis, Leonidas, Alcalay, Roy N., Rideout, Hardy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177829/
https://www.ncbi.nlm.nih.gov/pubmed/35676398
http://dx.doi.org/10.1038/s41531-022-00336-5

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