Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation

UPF3 is a key nonsense-mediated mRNA decay (NMD) factor required for mRNA surveillance and eukaryotic gene expression regulation. UPF3 exists as two paralogs (A and B) which are differentially expressed depending on cell type and developmental stage and believed to regulate NMD activity based on cel...

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Detalles Bibliográficos
Autores principales: Bufton, Joshua C, Powers, Kyle T, Szeto, Jenn-Yeu A, Toelzer, Christine, Berger, Imre, Schaffitzel, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177958/
https://www.ncbi.nlm.nih.gov/pubmed/35640974
http://dx.doi.org/10.1093/nar/gkac421

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