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Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications

Triplex-forming oligonucleotides (TFOs) are short, single-stranded oligomers that hybridise to a specific sequence of duplex DNA. TFOs can block transcription and thereby inhibit protein production, making them highly appealing in the field of antigene therapeutics. In this work, a primer extension...

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Detalles Bibliográficos
Autores principales:	McGorman, Bríonna, Fantoni, Nicolò Zuin, O’Carroll, Sinéad, Ziemele, Anna, El-Sagheer, Afaf H, Brown, Tom, Kellett, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177962/ https://www.ncbi.nlm.nih.gov/pubmed/35640595 http://dx.doi.org/10.1093/nar/gkac438

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