RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition

The RNF43_p.G659fs mutation occurs frequently in colorectal cancer, but its function remains poorly understood and there are no specific therapies directed against this alteration. In this study, we find that RNF43_p.G659fs promotes cell growth independent of Wnt signaling. We perform a drug repurpo...

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Detalles Bibliográficos
Autores principales: Fang, Lishan, Ford-Roshon, Dane, Russo, Max, O’Brien, Casey, Xiong, Xiaozhe, Gurjao, Carino, Grandclaudon, Maximilien, Raghavan, Srivatsan, Corsello, Steven M., Carr, Steven A., Udeshi, Namrata D., Berstler, James, Sicinska, Ewa, Ng, Kimmie, Giannakis, Marios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177965/
https://www.ncbi.nlm.nih.gov/pubmed/35676246
http://dx.doi.org/10.1038/s41467-022-30794-7

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