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Cytosolic microRNA-inducible nuclear translocation of Cas9 protein for disease-specific genome modification

MicroRNA-dependent mRNA decay plays an important role in gene silencing by facilitating posttranscriptional and translational repression. Inspired by this intrinsic nature of microRNA-mediated mRNA cleavage, here, we describe a microRNA-targeting mRNA as a switch platform called mRNA bridge mimetics...

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Detalles Bibliográficos
Autores principales:	Shin, Cheol-Hee, Park, Su Chan, Park, Il-Geun, Kim, Hyerim, An, Byoungha, Lee, Choongil, Kim, Sang-Heon, Lee, Juyong, Lee, Ji Min, Oh, Seung Ja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177975/ https://www.ncbi.nlm.nih.gov/pubmed/35640600 http://dx.doi.org/10.1093/nar/gkac431

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