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Mutations compensating for the fitness cost of rifampicin resistance in Escherichia coli exert pleiotropic effect on RNA polymerase catalysis

The spread of drug-resistant bacteria represents one of the most significant medical problems of our time. Bacterial fitness loss associated with drug resistance can be counteracted by acquisition of secondary mutations, thereby enhancing the virulence of such bacteria. Antibiotic rifampicin (Rif) t...

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Detalles Bibliográficos
Autores principales:	Kurepina, Natalia, Chudaev, Maxim, Kreiswirth, Barry N, Nikiforov, Vadim, Mustaev, Arkady
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177976/ https://www.ncbi.nlm.nih.gov/pubmed/35639764 http://dx.doi.org/10.1093/nar/gkac406

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