A loosened gating mechanism of RIG-I leads to autoimmune disorders

DDX58 encodes RIG-I, a cytosolic RNA sensor that ensures immune surveillance of nonself RNAs. Individuals with RIG-I(E510V) and RIG-I(Q517H) mutations have increased susceptibility to Singleton-Merten syndrome (SMS) defects, resulting in tissue-specific (mild) and classic (severe) phenotypes. The co...

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Detalles Bibliográficos
Autores principales: Lei, Yixuan, Fei, Panyu, Song, Bin, Shi, Wenjia, Luo, Cheng, Luo, Dahai, Li, Dan, Chen, Wei, Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177982/
https://www.ncbi.nlm.nih.gov/pubmed/35580046
http://dx.doi.org/10.1093/nar/gkac361

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