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Chromosomal synapsis defects can trigger oocyte apoptosis without elevating numbers of persistent DNA breaks above wild-type levels

Generation of haploid gametes depends on a modified version of homologous recombination in meiosis. Meiotic recombination is initiated by single-stranded DNA (ssDNA) ends originating from programmed DNA double-stranded breaks (DSBs) that are generated by the topoisomerase-related SPO11 enzyme. Meiot...

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Detalles Bibliográficos
Autores principales:	Ravindranathan, Ramya, Raveendran, Kavya, Papanikos, Frantzeskos, San-Segundo, Pedro A, Tóth, Attila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177993/ https://www.ncbi.nlm.nih.gov/pubmed/35580048 http://dx.doi.org/10.1093/nar/gkac355

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