The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis

Heparan sulfate is a highly modified O-linked glycan that performs diverse physiological roles in animal tissues. Though quickly modified, it is initially synthesised as a polysaccharide of alternating β-d-glucuronosyl and N-acetyl-α-d-glucosaminyl residues by exostosins. These enzymes generally pos...

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Detalles Bibliográficos
Autores principales: Wilson, L. F. L., Dendooven, T., Hardwick, S. W., Echevarría-Poza, A., Tryfona, T., Krogh, K. B. R. M., Chirgadze, D. Y., Luisi, B. F., Logan, D. T., Mani, K., Dupree, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178029/
https://www.ncbi.nlm.nih.gov/pubmed/35676258
http://dx.doi.org/10.1038/s41467-022-31048-2

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