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Human CD4(+)CD25(+)CD226(-) Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4(+)CD25(+)CD127(lo/-) Tregs for Adoptive Cell Therapy

Regulatory T cell (Treg) adoptive cell therapy (ACT) represents an emerging strategy for restoring immune tolerance in autoimmune diseases. Tregs are commonly purified using a CD4(+)CD25(+)CD127(lo/-) gating strategy, which yields a mixed population: 1) cells expressing the transcription factors, FO...

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Detalles Bibliográficos
Autores principales:	Brown, Matthew E., Peters, Leeana D., Hanbali, Seif R., Arnoletti, Juan M., Sachs, Lindsey K., Nguyen, Kayla Q., Carpenter, Emma B., Seay, Howard R., Fuhrman, Christopher A., Posgai, Amanda L., Shapiro, Melanie R., Brusko, Todd M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178079/ https://www.ncbi.nlm.nih.gov/pubmed/35693814 http://dx.doi.org/10.3389/fimmu.2022.873560

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