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Epidemiology of early esophageal adenocarcinoma

BACKGROUND/AIMS: Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined. METHODS: Surveillance Epidemiology and End Results (SEER) data were analyzed to determine ag...

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Autores principales: Hang, Thuy-Van P., Spiritos, Zachary, Gamboa, Anthony M., Chen, Zhengjia, Force, Seth, Patel, Vaishali, Chawla, Saurabh, Keilin, Steven, Saba, Nabil F., El-Rayes, Bassel, Cai, Qiang, Willingham, Field F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Gastrointestinal Endoscopy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178140/
https://www.ncbi.nlm.nih.gov/pubmed/35144364
http://dx.doi.org/10.5946/ce.2021.152
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author Hang, Thuy-Van P.
Spiritos, Zachary
Gamboa, Anthony M.
Chen, Zhengjia
Force, Seth
Patel, Vaishali
Chawla, Saurabh
Keilin, Steven
Saba, Nabil F.
El-Rayes, Bassel
Cai, Qiang
Willingham, Field F.
author_facet Hang, Thuy-Van P.
Spiritos, Zachary
Gamboa, Anthony M.
Chen, Zhengjia
Force, Seth
Patel, Vaishali
Chawla, Saurabh
Keilin, Steven
Saba, Nabil F.
El-Rayes, Bassel
Cai, Qiang
Willingham, Field F.
author_sort Hang, Thuy-Van P.
collection PubMed
description BACKGROUND/AIMS: Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined. METHODS: Surveillance Epidemiology and End Results (SEER) data were analyzed to determine age-adjusted incidence rates among major epithelial carcinomas, including EAC, from 1973 to 2017. The percent change in incidence over time was compared according to tumor subtype. Early T-stage, node-negative EAC without metastasis was examined from 2004 to 2017 when precise T-stage data were available. RESULTS: The percent change in annual incidence from 1973 to 2017 was 767% for EAC. Joinpoint analysis showed that the average annual percent change in EAC from 1973 to 2017 was 5.11% (95% confidence interval, 4.66%–5.56%). The annual percent change appeared to plateau between 2004 and 2017; however, early EAC decreased from 2010 to 2017, with an annual percent change of –5.78%. CONCLUSIONS: There has been a 7-fold increase in the incidence of EAC, which was significantly greater than that of the other major epithelial malignancies examined. More recently, the incidence of early EAC has been decreasing. Approximately one in five patients has node negative, potentially resectable early stage disease.
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spelling pubmed-91781402022-06-14 Epidemiology of early esophageal adenocarcinoma Hang, Thuy-Van P. Spiritos, Zachary Gamboa, Anthony M. Chen, Zhengjia Force, Seth Patel, Vaishali Chawla, Saurabh Keilin, Steven Saba, Nabil F. El-Rayes, Bassel Cai, Qiang Willingham, Field F. Clin Endosc Original Article BACKGROUND/AIMS: Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined. METHODS: Surveillance Epidemiology and End Results (SEER) data were analyzed to determine age-adjusted incidence rates among major epithelial carcinomas, including EAC, from 1973 to 2017. The percent change in incidence over time was compared according to tumor subtype. Early T-stage, node-negative EAC without metastasis was examined from 2004 to 2017 when precise T-stage data were available. RESULTS: The percent change in annual incidence from 1973 to 2017 was 767% for EAC. Joinpoint analysis showed that the average annual percent change in EAC from 1973 to 2017 was 5.11% (95% confidence interval, 4.66%–5.56%). The annual percent change appeared to plateau between 2004 and 2017; however, early EAC decreased from 2010 to 2017, with an annual percent change of –5.78%. CONCLUSIONS: There has been a 7-fold increase in the incidence of EAC, which was significantly greater than that of the other major epithelial malignancies examined. More recently, the incidence of early EAC has been decreasing. Approximately one in five patients has node negative, potentially resectable early stage disease. Korean Society of Gastrointestinal Endoscopy 2022-05 2022-02-11 /pmc/articles/PMC9178140/ /pubmed/35144364 http://dx.doi.org/10.5946/ce.2021.152 Text en Copyright © 2022 Korean Society of Gastrointestinal Endoscopy https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hang, Thuy-Van P.
Spiritos, Zachary
Gamboa, Anthony M.
Chen, Zhengjia
Force, Seth
Patel, Vaishali
Chawla, Saurabh
Keilin, Steven
Saba, Nabil F.
El-Rayes, Bassel
Cai, Qiang
Willingham, Field F.
Epidemiology of early esophageal adenocarcinoma
title Epidemiology of early esophageal adenocarcinoma
title_full Epidemiology of early esophageal adenocarcinoma
title_fullStr Epidemiology of early esophageal adenocarcinoma
title_full_unstemmed Epidemiology of early esophageal adenocarcinoma
title_short Epidemiology of early esophageal adenocarcinoma
title_sort epidemiology of early esophageal adenocarcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178140/
https://www.ncbi.nlm.nih.gov/pubmed/35144364
http://dx.doi.org/10.5946/ce.2021.152
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