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Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease

Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor that contains two CARD domains, an RNA helicase domain, and a C-terminal domain. RIG-I initiates antiviral innate immunity by recognizing exogenous viral RNAs/DNAs. However, some studies have reported that RIG-I activ...

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Autores principales: Wang, Hao, Yin, Jie, Gu, Xinyan, Shao, Wenhui, Jia, Zhanjun, Chen, Hongbing, Xia, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178270/
https://www.ncbi.nlm.nih.gov/pubmed/35693778
http://dx.doi.org/10.3389/fimmu.2022.893204
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author Wang, Hao
Yin, Jie
Gu, Xinyan
Shao, Wenhui
Jia, Zhanjun
Chen, Hongbing
Xia, Weiwei
author_facet Wang, Hao
Yin, Jie
Gu, Xinyan
Shao, Wenhui
Jia, Zhanjun
Chen, Hongbing
Xia, Weiwei
author_sort Wang, Hao
collection PubMed
description Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor that contains two CARD domains, an RNA helicase domain, and a C-terminal domain. RIG-I initiates antiviral innate immunity by recognizing exogenous viral RNAs/DNAs. However, some studies have reported that RIG-I activation leads to damage in various organs and tissues in diverse circumstances. Recent studies have shown that RIG-I is involved in cancer, lupus nephritis, immunoglobulin A nephropathy, Crohn’s disease, and atherosclerosis. These reports indicate that RIG-I not only participates in antiviral signaling pathways but also exerts an influence on non-viral infectious diseases. RIG-I is widely expressed in immune and non-immune cells including smooth muscle cells, endothelial cells, and cardiomyocytes. A succinct overview of RIG-I and its signaling pathways, with respect to the cardiovascular system, will aid in the development of novel therapeutics for cardiovascular diseases. In this review, we summarize the structure, activation, signaling pathways, and role of RIG-I in cardiovascular diseases.
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spelling pubmed-91782702022-06-10 Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease Wang, Hao Yin, Jie Gu, Xinyan Shao, Wenhui Jia, Zhanjun Chen, Hongbing Xia, Weiwei Front Immunol Immunology Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor that contains two CARD domains, an RNA helicase domain, and a C-terminal domain. RIG-I initiates antiviral innate immunity by recognizing exogenous viral RNAs/DNAs. However, some studies have reported that RIG-I activation leads to damage in various organs and tissues in diverse circumstances. Recent studies have shown that RIG-I is involved in cancer, lupus nephritis, immunoglobulin A nephropathy, Crohn’s disease, and atherosclerosis. These reports indicate that RIG-I not only participates in antiviral signaling pathways but also exerts an influence on non-viral infectious diseases. RIG-I is widely expressed in immune and non-immune cells including smooth muscle cells, endothelial cells, and cardiomyocytes. A succinct overview of RIG-I and its signaling pathways, with respect to the cardiovascular system, will aid in the development of novel therapeutics for cardiovascular diseases. In this review, we summarize the structure, activation, signaling pathways, and role of RIG-I in cardiovascular diseases. Frontiers Media S.A. 2022-05-26 /pmc/articles/PMC9178270/ /pubmed/35693778 http://dx.doi.org/10.3389/fimmu.2022.893204 Text en Copyright © 2022 Wang, Yin, Gu, Shao, Jia, Chen and Xia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Hao
Yin, Jie
Gu, Xinyan
Shao, Wenhui
Jia, Zhanjun
Chen, Hongbing
Xia, Weiwei
Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease
title Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease
title_full Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease
title_fullStr Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease
title_full_unstemmed Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease
title_short Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease
title_sort immune regulator retinoic acid-inducible gene i (rig-i) in the pathogenesis of cardiovascular disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178270/
https://www.ncbi.nlm.nih.gov/pubmed/35693778
http://dx.doi.org/10.3389/fimmu.2022.893204
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