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Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells

Fbxo7 is associated with cancer and Parkinson’s disease. Although Fbxo7 recruits substrates for SCF-type ubiquitin ligases, it also promotes Cdk6 activation in a ligase-independent fashion. We discovered PFKP, the gatekeeper of glycolysis, in a screen for Fbxo7 substrates. PFKP is an essential Cdk6...

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Detalles Bibliográficos
Autores principales:	Harris, Rebecca, Yang, Ming, Schmidt, Christina, Royet, Chloe, Singh, Sarbjit, Natarajan, Amarnath, Morris, May, Frezza, Christian, Laman, Heike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178409/ https://www.ncbi.nlm.nih.gov/pubmed/35670764 http://dx.doi.org/10.1083/jcb.202203095

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