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Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis
The brain has many connections with various organs. Recent advances have demonstrated the existence of a bidirectional central nervous system (CNS) and intestinal tract, that is, the brain-gut axis. Although studies have suggested that the brain and lung can communicate with each other through many...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178545/ https://www.ncbi.nlm.nih.gov/pubmed/35678887 http://dx.doi.org/10.1007/s10571-022-01238-z |
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author | Li, Chunyi Chen, Wenli Lin, Feng Li, Wenbin Wang, Ping Liao, Guolei Zhang, Lei |
author_facet | Li, Chunyi Chen, Wenli Lin, Feng Li, Wenbin Wang, Ping Liao, Guolei Zhang, Lei |
author_sort | Li, Chunyi |
collection | PubMed |
description | The brain has many connections with various organs. Recent advances have demonstrated the existence of a bidirectional central nervous system (CNS) and intestinal tract, that is, the brain-gut axis. Although studies have suggested that the brain and lung can communicate with each other through many pathways, whether there is a brain–lung axis remains still unknown. Based on previous findings, we put forward a hypothesis: there is a cross-talk between the central nervous system and the lung via neuroanatomical pathway, endocrine pathway, immune pathway, metabolites and microorganism pathway, gas pathway, that is, the brain–lung axis. Beyond the regulation of the physiological state in the body, bi-directional communication between the lung and the brain is associated with a variety of disease states, including lung diseases and CNS diseases. Exploring the brain–lung axis not only helps us to understand the development of the disease from different aspects, but also provides an important target for treatment strategies. |
format | Online Article Text |
id | pubmed-9178545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-91785452022-06-09 Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis Li, Chunyi Chen, Wenli Lin, Feng Li, Wenbin Wang, Ping Liao, Guolei Zhang, Lei Cell Mol Neurobiol Review Paper The brain has many connections with various organs. Recent advances have demonstrated the existence of a bidirectional central nervous system (CNS) and intestinal tract, that is, the brain-gut axis. Although studies have suggested that the brain and lung can communicate with each other through many pathways, whether there is a brain–lung axis remains still unknown. Based on previous findings, we put forward a hypothesis: there is a cross-talk between the central nervous system and the lung via neuroanatomical pathway, endocrine pathway, immune pathway, metabolites and microorganism pathway, gas pathway, that is, the brain–lung axis. Beyond the regulation of the physiological state in the body, bi-directional communication between the lung and the brain is associated with a variety of disease states, including lung diseases and CNS diseases. Exploring the brain–lung axis not only helps us to understand the development of the disease from different aspects, but also provides an important target for treatment strategies. Springer US 2022-06-09 2023 /pmc/articles/PMC9178545/ /pubmed/35678887 http://dx.doi.org/10.1007/s10571-022-01238-z Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Paper Li, Chunyi Chen, Wenli Lin, Feng Li, Wenbin Wang, Ping Liao, Guolei Zhang, Lei Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis |
title | Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis |
title_full | Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis |
title_fullStr | Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis |
title_full_unstemmed | Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis |
title_short | Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis |
title_sort | functional two-way crosstalk between brain and lung: the brain–lung axis |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178545/ https://www.ncbi.nlm.nih.gov/pubmed/35678887 http://dx.doi.org/10.1007/s10571-022-01238-z |
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