Combination of IM-Based Approaches to Unravel the Coexistence of Two Conformers on a Therapeutic Multispecific mAb

[Image: see text] Multispecific antibodies, which target multiple antigens at once, are emerging as promising therapeutic entities to offer more effective treatment than conventional monoclonal antibodies (mAbs). However, these highly complex mAb formats pose significant analytical challenges. We re...

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Detalles Bibliográficos
Autores principales: Deslignière, Evolène, Ollivier, Simon, Ehkirch, Anthony, Martelet, Armelle, Ropartz, David, Lechat, Nelly, Hernandez-Alba, Oscar, Menet, Jean-Michel, Clavier, Séverine, Rogniaux, Hélène, Genet, Bruno, Cianférani, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178554/
https://www.ncbi.nlm.nih.gov/pubmed/35604400
http://dx.doi.org/10.1021/acs.analchem.2c00928

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