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Wide-Line NMR Melting Diagrams, Their Thermodynamic Interpretation, and Secondary Structure Predictions for A30P and E46K α-Synuclein
[Image: see text] Parkinson’s disease is thought to be caused by aggregation of the intrinsically disordered protein, α-synuclein. Two amyloidogenic variants, A30P, and E46K familial mutants were investigated by wide-line (1)H NMR spectrometry as a completion of our earlier work on wild-type and A53...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178613/ https://www.ncbi.nlm.nih.gov/pubmed/35694516 http://dx.doi.org/10.1021/acsomega.2c00477 |