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Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report

Malignant transformation of Warthin's tumor into squamous cell carcinoma is rare. The present study reported on a case of a 67-year-old male patient diagnosed with this condition. Microscopically, the tumor was mainly composed of squamous cell carcinoma and lymphoid stroma. Furthermore, the squ...

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Autores principales: Shou, Leyi, Chen, Xiaodan, Yang, Junjie, Jiang, Yiqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178688/
https://www.ncbi.nlm.nih.gov/pubmed/35720470
http://dx.doi.org/10.3892/ol.2022.13322
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author Shou, Leyi
Chen, Xiaodan
Yang, Junjie
Jiang, Yiqian
author_facet Shou, Leyi
Chen, Xiaodan
Yang, Junjie
Jiang, Yiqian
author_sort Shou, Leyi
collection PubMed
description Malignant transformation of Warthin's tumor into squamous cell carcinoma is rare. The present study reported on a case of a 67-year-old male patient diagnosed with this condition. Microscopically, the tumor was mainly composed of squamous cell carcinoma and lymphoid stroma. Furthermore, the squamous cell carcinoma cells were arranged in a solid flake-like, papillary and cystic shape. Local bleeding was observed in the mass and a large number of lymphoid stroma-associated centers were observed between the cancer cells. The expression of cytokeratin (CK)5/6, P40, CK7, CK18, CK8 and MutS protein homolog 2 was detected by immunohistochemistry, in addition to Epstein-Barr encoding region in situ hybridization (−), Ki-67 (epithelial 25% +) and p53 (wild-type). The diagnosis of malignant transformation of Warthin's tumor into squamous cell carcinoma depends on the histopathology. The microscopic diagnosis is based on the dynamic process of scaling, atypical hyperplasia and cancerization of the eosinophilic columnar epithelium. Of note, it is also necessary to differentiate it from cervical malignant tumors such as lymphoepithelial carcinoma. The main clinical treatment is surgical resection with negative margins.
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spelling pubmed-91786882022-06-16 Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report Shou, Leyi Chen, Xiaodan Yang, Junjie Jiang, Yiqian Oncol Lett Articles Malignant transformation of Warthin's tumor into squamous cell carcinoma is rare. The present study reported on a case of a 67-year-old male patient diagnosed with this condition. Microscopically, the tumor was mainly composed of squamous cell carcinoma and lymphoid stroma. Furthermore, the squamous cell carcinoma cells were arranged in a solid flake-like, papillary and cystic shape. Local bleeding was observed in the mass and a large number of lymphoid stroma-associated centers were observed between the cancer cells. The expression of cytokeratin (CK)5/6, P40, CK7, CK18, CK8 and MutS protein homolog 2 was detected by immunohistochemistry, in addition to Epstein-Barr encoding region in situ hybridization (−), Ki-67 (epithelial 25% +) and p53 (wild-type). The diagnosis of malignant transformation of Warthin's tumor into squamous cell carcinoma depends on the histopathology. The microscopic diagnosis is based on the dynamic process of scaling, atypical hyperplasia and cancerization of the eosinophilic columnar epithelium. Of note, it is also necessary to differentiate it from cervical malignant tumors such as lymphoepithelial carcinoma. The main clinical treatment is surgical resection with negative margins. D.A. Spandidos 2022-05-12 /pmc/articles/PMC9178688/ /pubmed/35720470 http://dx.doi.org/10.3892/ol.2022.13322 Text en Copyright: © Shou et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Shou, Leyi
Chen, Xiaodan
Yang, Junjie
Jiang, Yiqian
Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report
title Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report
title_full Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report
title_fullStr Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report
title_full_unstemmed Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report
title_short Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report
title_sort malignant transformation of warthin's tumor into squamous cell carcinoma: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178688/
https://www.ncbi.nlm.nih.gov/pubmed/35720470
http://dx.doi.org/10.3892/ol.2022.13322
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