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Discovery of Histone Deacetylase Inhibitor Using Molecular Modeling and Free Energy Calculations
[Image: see text] The histone acetylation–deacetylation at lysine regulates the functions of many cellular proteins. An increased expression of HDAC6 can cause an increased amount of deacetylated histones, which leads to an inhibition of gene expression and has been associated with cancer cell proli...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178742/ https://www.ncbi.nlm.nih.gov/pubmed/35694501 http://dx.doi.org/10.1021/acsomega.2c01572 |