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Enzymatic Characterization of In Vitro Activity of RNA Methyltransferase PCIF1 on DNA

[Image: see text] PCIF1 and FTO are a pair of human mRNA cap-specific modification enzymes that have opposing activities. PCIF1 adds a methyl group to the N6-position of 2′O-methyladenosine (A(m)), generating N6, 2′O-dimethyladenosine (m(6)A(m)), when A(m) is the cap-proximal nucleotide. FTO removes...

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Detalles Bibliográficos
Autores principales:	Yu, Dan, Zhou, Jujun, Chen, Qin, Wu, Tao, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178792/ https://www.ncbi.nlm.nih.gov/pubmed/35605980 http://dx.doi.org/10.1021/acs.biochem.2c00134

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