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Germinal center expansion but not plasmablast differentiation is proportional to peptide-MHCII density via CD40-CD40L signaling strength

T follicular helper (TFH) cells promote expansion of germinal center (GC) B cells and plasma cell differentiation. Whether cognate peptide-MHCII (pMHCII) density instructs selection and cell fate decisions in a quantitative manner remains unclear. Using αDEC205-OVA to differentially deliver OVA pept...

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Detalles Bibliográficos
Autores principales:	Jing, Zhixin, McCarron, Mark J., Dustin, Michael L., Fooksman, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178878/ https://www.ncbi.nlm.nih.gov/pubmed/35508132 http://dx.doi.org/10.1016/j.celrep.2022.110763

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