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Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage
Coronavirus disease 2019 (COVID-19) has caused a global pandemic impacting over 200 countries/regions and more than 200 million patients worldwide. Among the infected patients, there is a high prevalence of COVID-19-related cardiovascular injuries. However, the specific mechanisms linking cardiovasc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Huazhong University of Science and Technology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178934/ https://www.ncbi.nlm.nih.gov/pubmed/35678914 http://dx.doi.org/10.1007/s11596-022-2529-0 |
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author | Chen, Xing Qiao, Wei-hua Cao, Hong Shi, Jia-wei Du, Xin-ling Dong, Nian-guo |
author_facet | Chen, Xing Qiao, Wei-hua Cao, Hong Shi, Jia-wei Du, Xin-ling Dong, Nian-guo |
author_sort | Chen, Xing |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) has caused a global pandemic impacting over 200 countries/regions and more than 200 million patients worldwide. Among the infected patients, there is a high prevalence of COVID-19-related cardiovascular injuries. However, the specific mechanisms linking cardiovascular damage and COVID-19 remain unclear. The COVID-19 pandemic also has exacerbated the mental health burden of humans. Considering the close association between neuroimmune interactions and cardiovascular disease, this review assessed the complex pathophysiological mechanisms connecting neuroimmune interactions and cardiovascular disease. It was revealed that the mental health burden might be a pivotal accomplice causing COVID-19-associated cardiovascular damage. Specifically, the proinflammatory status of patients with a terrible mood state is closely related to overdrive of the hypothalamus-pituitary-adrenal (HPA) axis, sympathovagal imbalance, and endothelial dysfunction, which lead to an increased risk of developing cardiovascular injury during COVID-19. Therefore, during the prevention and treatment of cardiovascular complications in COVID-19 patients, particular attention should be given to relieve the mental health burden of these patients. |
format | Online Article Text |
id | pubmed-9178934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Huazhong University of Science and Technology |
record_format | MEDLINE/PubMed |
spelling | pubmed-91789342022-06-09 Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage Chen, Xing Qiao, Wei-hua Cao, Hong Shi, Jia-wei Du, Xin-ling Dong, Nian-guo Curr Med Sci Article Coronavirus disease 2019 (COVID-19) has caused a global pandemic impacting over 200 countries/regions and more than 200 million patients worldwide. Among the infected patients, there is a high prevalence of COVID-19-related cardiovascular injuries. However, the specific mechanisms linking cardiovascular damage and COVID-19 remain unclear. The COVID-19 pandemic also has exacerbated the mental health burden of humans. Considering the close association between neuroimmune interactions and cardiovascular disease, this review assessed the complex pathophysiological mechanisms connecting neuroimmune interactions and cardiovascular disease. It was revealed that the mental health burden might be a pivotal accomplice causing COVID-19-associated cardiovascular damage. Specifically, the proinflammatory status of patients with a terrible mood state is closely related to overdrive of the hypothalamus-pituitary-adrenal (HPA) axis, sympathovagal imbalance, and endothelial dysfunction, which lead to an increased risk of developing cardiovascular injury during COVID-19. Therefore, during the prevention and treatment of cardiovascular complications in COVID-19 patients, particular attention should be given to relieve the mental health burden of these patients. Huazhong University of Science and Technology 2022-06-08 2022 /pmc/articles/PMC9178934/ /pubmed/35678914 http://dx.doi.org/10.1007/s11596-022-2529-0 Text en © Huazhong University of Science and Technology 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Chen, Xing Qiao, Wei-hua Cao, Hong Shi, Jia-wei Du, Xin-ling Dong, Nian-guo Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage |
title | Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage |
title_full | Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage |
title_fullStr | Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage |
title_full_unstemmed | Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage |
title_short | Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage |
title_sort | role of neuroimmune interactions in covid-19-related cardiovascular damage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178934/ https://www.ncbi.nlm.nih.gov/pubmed/35678914 http://dx.doi.org/10.1007/s11596-022-2529-0 |
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