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Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese

INTRODUCTION: Oral health and genetic factors can independently influence the risk of developing esophageal squamous cell carcinoma (ESCC). OBJECTIVES: The primary objective of this study was to investigate the interactive effects of oral health and genetic factors on ESCC risk. METHODS: This was a...

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Autores principales: Zhao, Renjia, Li, Xiaoxiao, Yang, Xiaorong, Zhang, Tiejun, Lu, Ming, Ye, Weimin, Jin, Li, Suo, Chen, Chen, Xingdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179002/
http://dx.doi.org/10.1177/10732748221075811
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author Zhao, Renjia
Li, Xiaoxiao
Yang, Xiaorong
Zhang, Tiejun
Lu, Ming
Ye, Weimin
Jin, Li
Suo, Chen
Chen, Xingdong
author_facet Zhao, Renjia
Li, Xiaoxiao
Yang, Xiaorong
Zhang, Tiejun
Lu, Ming
Ye, Weimin
Jin, Li
Suo, Chen
Chen, Xingdong
author_sort Zhao, Renjia
collection PubMed
description INTRODUCTION: Oral health and genetic factors can independently influence the risk of developing esophageal squamous cell carcinoma (ESCC). OBJECTIVES: The primary objective of this study was to investigate the interactive effects of oral health and genetic factors on ESCC risk. METHODS: This was a matched case-control study with 927 ESCC patients and 1701 matched controls. We selected 101 candidate single nucleotide polymorphisms (SNPs) from 59 genes that were associated with ESCC. Oral health was assessed based on tooth-brushing frequency, tooth loss, and age at the time of first tooth loss. An unconditional logistic regression model was employed in which SNP–oral health interactions were assessed as risk factors for ESCC, after adjusting for age and sex. A genetic risk score (GRS) analysis was conducted. RESULTS: The association between GRS and ESCC and the synergistic effect of GRS and oral health on ESCC were examined. Daily frequency of tooth-brushing was found to interact with 5 SNPs, rs3765524, rs753724, rs994771, rs3781264, and rs11187842, to increase the risk of ESCC. In particular, individuals with genotype TT of rs3765524 who brushed their teeth less than twice a day had a 5.13-times higher risk of ESCC than those with genotype CC who brushed their teeth at least twice a day. Furthermore, tooth loss interacted with two SNPs: rs1159918 from ADH1B and rs3813867 from CYP2E1. CONCLUSION: Oral health may interact with genetic factors increasing ESCC risk, which provides new insights into the relationship between ESCC and gene–lifestyle interactions which can be used for disease prevention.
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spelling pubmed-91790022022-06-10 Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese Zhao, Renjia Li, Xiaoxiao Yang, Xiaorong Zhang, Tiejun Lu, Ming Ye, Weimin Jin, Li Suo, Chen Chen, Xingdong Cancer Control Original Research Article INTRODUCTION: Oral health and genetic factors can independently influence the risk of developing esophageal squamous cell carcinoma (ESCC). OBJECTIVES: The primary objective of this study was to investigate the interactive effects of oral health and genetic factors on ESCC risk. METHODS: This was a matched case-control study with 927 ESCC patients and 1701 matched controls. We selected 101 candidate single nucleotide polymorphisms (SNPs) from 59 genes that were associated with ESCC. Oral health was assessed based on tooth-brushing frequency, tooth loss, and age at the time of first tooth loss. An unconditional logistic regression model was employed in which SNP–oral health interactions were assessed as risk factors for ESCC, after adjusting for age and sex. A genetic risk score (GRS) analysis was conducted. RESULTS: The association between GRS and ESCC and the synergistic effect of GRS and oral health on ESCC were examined. Daily frequency of tooth-brushing was found to interact with 5 SNPs, rs3765524, rs753724, rs994771, rs3781264, and rs11187842, to increase the risk of ESCC. In particular, individuals with genotype TT of rs3765524 who brushed their teeth less than twice a day had a 5.13-times higher risk of ESCC than those with genotype CC who brushed their teeth at least twice a day. Furthermore, tooth loss interacted with two SNPs: rs1159918 from ADH1B and rs3813867 from CYP2E1. CONCLUSION: Oral health may interact with genetic factors increasing ESCC risk, which provides new insights into the relationship between ESCC and gene–lifestyle interactions which can be used for disease prevention. SAGE Publications 2022-06-07 /pmc/articles/PMC9179002/ http://dx.doi.org/10.1177/10732748221075811 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Zhao, Renjia
Li, Xiaoxiao
Yang, Xiaorong
Zhang, Tiejun
Lu, Ming
Ye, Weimin
Jin, Li
Suo, Chen
Chen, Xingdong
Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese
title Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese
title_full Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese
title_fullStr Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese
title_full_unstemmed Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese
title_short Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese
title_sort association of esophageal squamous cell carcinoma with the interaction between poor oral health and single nucleotide polymorphisms in regulating cell cycles and angiogenesis: a case-control study in high-incidence chinese
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179002/
http://dx.doi.org/10.1177/10732748221075811
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