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Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio

Leading causes of death in industrialized countries are traumatic injuries and acquired disability, and entry to the emergency department in childhood. TBI (traumatic brain injury) may involve the onset of both primary lesions and a complex immune response (sterile immune reaction to brain injury),...

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Autores principales: Marchese, Pietro, Lardone, Chiara, Canepele, Alessia, Biondi, Samanta, Roggi, Costantino, Massart, Francesco, Bonuccelli, Alice, Peroni, Diego G., Giotta Lucifero, Alice, Luzzi, Sabino, Foiadelli, Thomas, Orsini, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179059/
https://www.ncbi.nlm.nih.gov/pubmed/35441607
http://dx.doi.org/10.23750/abm.v92iS4.12666
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author Marchese, Pietro
Lardone, Chiara
Canepele, Alessia
Biondi, Samanta
Roggi, Costantino
Massart, Francesco
Bonuccelli, Alice
Peroni, Diego G.
Giotta Lucifero, Alice
Luzzi, Sabino
Foiadelli, Thomas
Orsini, Alessandro
author_facet Marchese, Pietro
Lardone, Chiara
Canepele, Alessia
Biondi, Samanta
Roggi, Costantino
Massart, Francesco
Bonuccelli, Alice
Peroni, Diego G.
Giotta Lucifero, Alice
Luzzi, Sabino
Foiadelli, Thomas
Orsini, Alessandro
author_sort Marchese, Pietro
collection PubMed
description Leading causes of death in industrialized countries are traumatic injuries and acquired disability, and entry to the emergency department in childhood. TBI (traumatic brain injury) may involve the onset of both primary lesions and a complex immune response (sterile immune reaction to brain injury), which, in addition to neuro-protective effects, can mediate secondary neurological injury. The neutrophil-to-lymphocyte ratio (NLR), as a circulating inflammatory marker, has been related to outcomes in adult patients with non-neurologic diseases (such as gut tumours) or neurologic diseases (such as stroke or brain tumours), and to the prognosis of traumatic brain injury in adolescents and adults. However, the potential role of NLR in predicting outcomes in paediatric head trauma is not clearly defined. The aim of this retrospective observational study is to evaluate the association between clinical features predictive of intracranial and extracranial lesions in TBI and NLR and to establish whether an elevation of NLR is indirectly associated with adverse outcomes in pediatric patients with TBI. We analysed a sample of 219 pediatric patients, between 2-18 years old, after a TBI, and evaluated if differences in NLR were associated with neurological signs or positive CT in pediatric patients. We then compared the NLR values between healthy subjects and patients with TBI. (www.actabiomedica.it)
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spelling pubmed-91790592022-07-05 Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio Marchese, Pietro Lardone, Chiara Canepele, Alessia Biondi, Samanta Roggi, Costantino Massart, Francesco Bonuccelli, Alice Peroni, Diego G. Giotta Lucifero, Alice Luzzi, Sabino Foiadelli, Thomas Orsini, Alessandro Acta Biomed Original Article Leading causes of death in industrialized countries are traumatic injuries and acquired disability, and entry to the emergency department in childhood. TBI (traumatic brain injury) may involve the onset of both primary lesions and a complex immune response (sterile immune reaction to brain injury), which, in addition to neuro-protective effects, can mediate secondary neurological injury. The neutrophil-to-lymphocyte ratio (NLR), as a circulating inflammatory marker, has been related to outcomes in adult patients with non-neurologic diseases (such as gut tumours) or neurologic diseases (such as stroke or brain tumours), and to the prognosis of traumatic brain injury in adolescents and adults. However, the potential role of NLR in predicting outcomes in paediatric head trauma is not clearly defined. The aim of this retrospective observational study is to evaluate the association between clinical features predictive of intracranial and extracranial lesions in TBI and NLR and to establish whether an elevation of NLR is indirectly associated with adverse outcomes in pediatric patients with TBI. We analysed a sample of 219 pediatric patients, between 2-18 years old, after a TBI, and evaluated if differences in NLR were associated with neurological signs or positive CT in pediatric patients. We then compared the NLR values between healthy subjects and patients with TBI. (www.actabiomedica.it) Mattioli 1885 2021 2021-08-26 /pmc/articles/PMC9179059/ /pubmed/35441607 http://dx.doi.org/10.23750/abm.v92iS4.12666 Text en Copyright: © 2021 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Original Article
Marchese, Pietro
Lardone, Chiara
Canepele, Alessia
Biondi, Samanta
Roggi, Costantino
Massart, Francesco
Bonuccelli, Alice
Peroni, Diego G.
Giotta Lucifero, Alice
Luzzi, Sabino
Foiadelli, Thomas
Orsini, Alessandro
Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio
title Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio
title_full Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio
title_fullStr Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio
title_full_unstemmed Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio
title_short Pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio
title_sort pediatric traumatic brain injury: a new relation between outcome and neutrophil-to-lymphocite ratio
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179059/
https://www.ncbi.nlm.nih.gov/pubmed/35441607
http://dx.doi.org/10.23750/abm.v92iS4.12666
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