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Improving antibody affinity through in vitro mutagenesis in complementarity determining regions

High-affinity antibodies are widely used in diagnostics and for the treatment of human diseases. However, most antibodies are isolated from semi-synthetic libraries by phage display and do not possess in vivo affinity maturation, which is triggered by antigen immunization. It is therefore necessary...

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Detalles Bibliográficos
Autores principales:	Ye, Wei, Liu, Xiaoyu, He, Ruiting, Gou, Liming, Lu, Ming, Yang, Gang, Wen, Jiaqi, Wang, Xufei, Liu, Fang, Ma, Sujuan, Qian, Weifeng, Jia, Shaochang, Ding, Tong, Sun, Luan, Gao, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Editorial Department of Journal of Biomedical Research 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179109/ https://www.ncbi.nlm.nih.gov/pubmed/35545451 http://dx.doi.org/10.7555/JBR.36.20220003

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