Autoreactive CD8(+) T cells are restrained by an exhaustion-like program that is maintained by LAG3

Impaired chronic viral and tumor clearance has been attributed to CD8(+) T cell exhaustion, a differentiation state in which T cells have reduced and altered effector function that can be partially reversed upon blockade of inhibitory receptors. The role of the exhaustion program and transcriptional...

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Detalles Bibliográficos
Autores principales: Grebinoski, Stephanie, Zhang, Qianxia, Cillo, Anthony R, Manne, Sasikanth, Xiao, Hanxi, Brunazzi, Erin A., Tabib, Tracy, Cardello, Carly, Lian, Christine G., Murphy, George F., Lafyatis, Robert, Wherry, E. John, Das, Jishnu, Workman, Creg J., Vignali, Dario A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179227/
https://www.ncbi.nlm.nih.gov/pubmed/35618829
http://dx.doi.org/10.1038/s41590-022-01210-5

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