Cargando…

The AKT1E17K Allele Promotes Breast Cancer in Mice

SIMPLE SUMMARY: The main finding reported in this manuscript is that the gain-of-function mutation AKT1E17K is a bona fide oncogene for mammary epithelium, being able to efficiently initiate breast cancer in mice. On the basis of high-molecular-weight cytokeratins expressed by AKT1E17K-derived tumor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malanga, Donatella, Laudanna, Carmelo, Mirante, Teresa, Colelli, Fabiana, Migliozzi, Simona, Zoppoli, Pietro, Santamaria, Gianluca, Roberto, Luca, De Marco, Carmela, Scarfò, Marzia, Montanaro, Donatella, Paciello, Orlando, Papparella, Serenella, Mignogna, Chiara, Baldi, Alfonso, Viglietto, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179273/ https://www.ncbi.nlm.nih.gov/pubmed/35681625 http://dx.doi.org/10.3390/cancers14112645

Ejemplares similares

AKT1(E17K) Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer
por: Malanga, Donatella, et al.
Publicado: (2016)

Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing
por: Oliveira, Duarte Mendes, et al.
Publicado: (2018)

Identification of copy number alterations in colon cancer from analysis of amplicon-based next generation sequencing data
por: Oliveira, Duarte Mendes, et al.
Publicado: (2018)

Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer
por: De Marco, Carmela, et al.
Publicado: (2017)

Simultaneous identification of clinically relevant single nucleotide variants, copy number alterations and gene fusions in solid tumors by targeted next-generation sequencing
por: Oliveira, Duarte Mendes, et al.
Publicado: (2018)

The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells
por: Malanga, Donatella, et al.
Publicado: (2015)

Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells
por: Guerriero, Ilaria, et al.
Publicado: (2016)

Correction: Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells
por: Guerriero, Ilaria, et al.
Publicado: (2022)

Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene
por: Mendes Oliveira, Duarte, et al.
Publicado: (2018)

Correction to: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene
por: Oliveira, Duarte Mendes, et al.
Publicado: (2018)

The correlation between cardiac and skeletal muscle pathology in animal models of idiopathic inflammatory myopathies
por: Prisco, Francesco, et al.
Publicado: (2020)

Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase
por: Scrima, Marianna, et al.
Publicado: (2012)

Mutant AKT1-E17K is oncogenic in lung epithelial cells
por: De Marco, Carmela, et al.
Publicado: (2015)

Pneumoperitoneum Modifies Serum and Tissue CCL2-CCL5 Expression in Mice
por: Papparella, Alfonso, et al.
Publicado: (2020)

Aberrant Signaling through the HER2-ERK1/2 Pathway is Predictive of Reduced Disease-Free and Overall Survival in Early Stage Non-Small Cell Lung Cancer (NSCLC) Patients
por: Scrima, Marianna, et al.
Publicado: (2017)

Spheres Derived from Lung Adenocarcinoma Pleural Effusions: Molecular Characterization and Tumor Engraftment
por: Mancini, Rita, et al.
Publicado: (2011)

Immunopathological Response, Histological Changes, Parasitic Burden, and Egg Output in Sheep Naturally Infected by Dicrocoelium dendriticum
por: Piegari, Giuseppe, et al.
Publicado: (2021)

Implication of the NLRP3 Inflammasome in Bovine Age-Related Sarcopenia
por: De Biase, Davide, et al.
Publicado: (2021)

Immunopathological Features of Canine Myocarditis Associated with Leishmania infantum Infection
por: Costagliola, Alessandro, et al.
Publicado: (2016)

Genome-wide analysis of copy number alterations led to the characterisation of PDCD10 as oncogene in ovarian cancer
por: De Marco, Carmela, et al.
Publicado: (2021)

Pathologic characterization of white striping myopathy in broiler chickens
por: Prisco, Francesco, et al.
Publicado: (2021)

RNAScope in situ Hybridization as a Novel Technique for the Assessment of c-KIT mRNA Expression in Canine Mast Cell Tumor
por: De Biase, Davide, et al.
Publicado: (2021)

Leishmania spp.-Infected Dogs Have Circulating Anti-Skeletal Muscle Autoantibodies Recognizing SERCA1
por: Prisco, Francesco, et al.
Publicado: (2021)

Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity
por: Leone, Vincenza, et al.
Publicado: (2015)

Evaluation of the Local Immune Response to Hydatid Cysts in Sheep Liver
por: De Biase, Davide, et al.
Publicado: (2023)

Bovine Papillomavirus Type 2 Infection and a Series of Mesenchymal Tumors of the Urinary Bladder in Cattle
por: Martano, Manuela, et al.
Publicado: (2013)

Ferritin Heavy Subunit Silencing Blocks the Erythroid Commitment of K562 Cells via miR-150 up-Regulation and GATA-1 Repression
por: Zolea, Fabiana, et al.
Publicado: (2017)

Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy
por: Aversa, Ilenia, et al.
Publicado: (2020)

Reproducibility and Feasibility of Classification and National Guidelines for Histological Diagnosis of Canine Mammary Gland Tumours: A Multi-Institutional Ring Study
por: Papparella, Serenella, et al.
Publicado: (2022)

Ensemble of Gene Signatures Identifies Novel Biomarkers in Colorectal Cancer Activated through PPARγ and TNFα Signaling
por: Pagnotta, Stefano Maria, et al.
Publicado: (2013)

Detection of Natural Resistance-Associated Substitutions by Ion Semiconductor Technology in HCV1b Positive, Direct-Acting Antiviral Agents-Naïve Patients
por: Marascio, Nadia, et al.
Publicado: (2016)

Design and Characterization of Glyceryl Monooleate-Nanostructures Containing Doxorubicin Hydrochloride
por: Gagliardi, Agnese, et al.
Publicado: (2020)

Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells
por: Nassa, Giovanni, et al.
Publicado: (2019)

Co-regulated expression of alpha and beta mRNAs encoding HLA-DR surface heterodimers is mediated by the MHCII RNA operon
por: Pisapia, Laura, et al.
Publicado: (2013)

Antioxidant and Anti-Inflammatory Agents from the Sea: A Molecular Treasure for New Potential Drugs
por: Vasarri, Marzia, et al.
Publicado: (2022)

News and Updates from 2022 on Antioxidant and Anti-Inflammatory Properties of Marine Products
por: Vasarri, Marzia, et al.
Publicado: (2022)

Angiostrongylus vasorum: epidemiological, clinical and histopathological insights
por: Rinaldi, Laura, et al.
Publicado: (2014)

Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning
por: Fagman, Henrik, et al.
Publicado: (2011)

AKT mutant allele-specific activation dictates pharmacologic sensitivities
por: Shrestha Bhattarai, Tripti, et al.
Publicado: (2022)

Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer
por: Parcesepe, Pietro, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_u359flj56s8kdsgkpp1vggmdd3