Cargando…

LFA1 Activation: Insights from a Single-Molecule Approach

Integrin LFA1 is a cell adhesion receptor expressed exclusively in leukocytes, and plays crucial roles in lymphocyte trafficking, antigen recognition, and effector functions. Since the discovery that the adhesiveness of LFA1 can be dynamically changed upon stimulation, one challenge has been underst...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kondo, Naoyuki, Ueda, Yoshihiro, Kinashi, Tatsuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179313/ https://www.ncbi.nlm.nih.gov/pubmed/35681446 http://dx.doi.org/10.3390/cells11111751

Ejemplares similares

Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow
por: Kamioka, Yuji, et al.
Publicado: (2023)

NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization
por: Kondo, Naoyuki, et al.
Publicado: (2017)

MST1/2 Balance Immune Activation and Tolerance by Orchestrating Adhesion, Transcription, and Organelle Dynamics in Lymphocytes
por: Ueda, Yoshihiro, et al.
Publicado: (2020)

The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes
por: Horitani, Shunsuke, et al.
Publicado: (2023)

Antigen-Specific Suppression and Immunological Synapse Formation by Regulatory T Cells Require the Mst1 Kinase
por: Tomiyama, Takashi, et al.
Publicado: (2013)

Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1
por: Ueda, Yoshihiro, et al.
Publicado: (2023)

Neutrophil arrest by LFA-1 activation
por: Lefort, Craig T., et al.
Publicado: (2012)

Role of LFA-1 and ICAM-1 in Cancer
por: Reina, Manuel, et al.
Publicado: (2017)

LFA-1 Activation in T-Cell Migration and Immunological Synapse Formation
por: Shi, Huiping, et al.
Publicado: (2023)

Involvement of LFA-1 in lymphoma invasion and metastasis demonstrated with LFA-1-deficient mutants
Publicado: (1989)

Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes
por: Manikwar, Prakash, et al.
Publicado: (2011)

ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway
Publicado: (1993)

Suppression of LFA-1 Expression by Spermine Is Associated with Enhanced Methylation of ITGAL, the LFA-1 Promoter Area
por: Kano, Yoshihiko, et al.
Publicado: (2013)

Identification and X-ray Co-crystal Structure of a Small-Molecule Activator of LFA-1-ICAM-1 Binding**
por: Hintersteiner, Martin, et al.
Publicado: (2014)

LFA-1 in T Cell Migration and Differentiation
por: Walling, Brandon L., et al.
Publicado: (2018)

Probing Single Icam-1/Lfa-1 Interaction under External Force
por: Zhang, Xiaohui, et al.
Publicado: (2002)

Major histocompatibility complex-restricted antigen receptor on T cells. VIII. Role of the LFA-1 molecule
Publicado: (1985)

DNA replication machinery: Insights from in vitro single-molecule approaches
por: Bocanegra, Rebeca, et al.
Publicado: (2021)

HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)
por: Hioe, Catarina E., et al.
Publicado: (2011)

Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments
por: Askanase, Anca, et al.
Publicado: (2015)

A novel LFA-1 activation epitope maps to the I domain
Publicado: (1993)

Signaling by lymphocyte function-associated antigen 1 (LFA-1) in B cells: enhanced antigen presentation after stimulation through LFA-1
Publicado: (1992)

LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease
por: Pflugfelder, Stephen C., et al.
Publicado: (2017)

Live-Cell FRET Imaging Reveals a Role of Extracellular Signal-Regulated Kinase Activity Dynamics in Thymocyte Motility
por: Konishi, Yoshinobu, et al.
Publicado: (2018)

Motility and ultrastructure of large granular lymphocytes on lipid bilayers reconstituted with adhesion receptors LFA-1, ICAM-1, and two isoforms of LFA-3
Publicado: (1991)

Design, synthesis, and LFA-1/ICAM-1 antagonist activity evaluation of Lifitegrast analogues
por: Du, Guoxin, et al.
Publicado: (2022)

A Functional Analysis on the Interspecies Interaction between Mouse LFA-1 and Human Intercellular Adhesion Molecule-1 at the Cell Level
por: Núñez, David, et al.
Publicado: (2017)

The Role of LFA-1 for the Differentiation and Function of Regulatory T Cells—Lessons Learned from Different Transgenic Mouse Models
por: Klaus, Tanja, et al.
Publicado: (2023)

Neuraminidase-3 Is a Negative Regulator of LFA-1 Adhesion
por: Howlader, Md. Amran, et al.
Publicado: (2019)

Divalent cation regulation of the function of the leukocyte integrin LFA-1
Publicado: (1992)

Importance of integrin LFA-1 deactivation for the generation of immune responses
por: Semmrich, Monika, et al.
Publicado: (2005)

The Use of Lymphocyte Function–Associated Antigen (Lfa)-1–Deficient Mice to Determine the Role of Lfa-1, Mac-1, and α4 Integrin in the Inflammatory Response of Neutrophils
por: Henderson, Robert B., et al.
Publicado: (2001)

The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation
por: Ma, Victor Pui-Yan, et al.
Publicado: (2022)

Thymocyte Development of Humanized Mice Is Promoted by Interactions with Human-Derived Antigen Presenting Cells upon Immunization
por: Fukuhara, Takataro, et al.
Publicado: (2023)

Thermal conductance of Teflon and Polyethylene: Insight from an atomistic, single-molecule level
por: Buerkle, Marius, et al.
Publicado: (2017)

Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-mediated cell fusion but not for viral transmission
Publicado: (1991)

LFA-1 immunodeficiency disease. Definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in hybrid cells
Publicado: (1986)

Activation of LFA-1 through a Ca2(+)-dependent epitope stimulates lymphocyte adhesion
Publicado: (1991)

Calpain 2 Controls Turnover of LFA-1 Adhesions on Migrating T Lymphocytes
por: Svensson, Lena, et al.
Publicado: (2010)

Imaging of atherosclerosis, targeting LFA-1 on inflammatory cells with (111)In-DANBIRT
por: Meester, E. J., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_tvo9mceqqsqt4683sptrqpjph8