A Histone Deacetylase Inhibitor Induces Acetyl-CoA Depletion Leading to Lethal Metabolic Stress in RAS-Pathway Activated Cells

SIMPLE SUMMARY: Epigenetic therapies have been difficult to translate to solid tumors, in part because a lack of a full mechanistic understanding has not allowed the selection of tumors most likely to benefit from the therapies. Here we identified a RAS-phenotype that can be targeted by the histone...

Descripción completa

Detalles Bibliográficos
Autores principales: Basseville, Agnes, Violet, Pierre-Christian, Safari, Maryam, Sourbier, Carole, Linehan, W. Marston, Robey, Robert W., Levine, Mark, Sackett, Dan L., Bates, Susan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179484/
https://www.ncbi.nlm.nih.gov/pubmed/35681624
http://dx.doi.org/10.3390/cancers14112643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179484/
https://www.ncbi.nlm.nih.gov/pubmed/35681624
http://dx.doi.org/10.3390/cancers14112643

Ejemplares similares