Insights into the Possible Molecular Mechanisms of Resistance to PARP Inhibitors

SIMPLE SUMMARY: The increasingly wide use of PARP inhibitors in breast, ovarian, pancreatic, and prostate cancers harbouring a pathogenic variant in BRCA1 or BRCA2 has highlighted the problem of resistance to therapy. This review summarises the complex interactions between PARP1, cell cycle regulati...

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Detalles Bibliográficos
Autores principales: Piombino, Claudia, Cortesi, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179506/
https://www.ncbi.nlm.nih.gov/pubmed/35681784
http://dx.doi.org/10.3390/cancers14112804

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