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Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function
The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles. Recent advances in the molecular mechanisms regulating lymphangiogenes...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179518/ https://www.ncbi.nlm.nih.gov/pubmed/35681445 http://dx.doi.org/10.3390/cells11111750 |
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author | Singla, Bhupesh Aithabathula, Ravi Varma Kiran, Sonia Kapil, Shweta Kumar, Santosh Singh, Udai P. |
author_facet | Singla, Bhupesh Aithabathula, Ravi Varma Kiran, Sonia Kapil, Shweta Kumar, Santosh Singh, Udai P. |
author_sort | Singla, Bhupesh |
collection | PubMed |
description | The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles. Recent advances in the molecular mechanisms regulating lymphangiogenesis have opened a new area of research on reparative lymphangiogenesis for the treatment of various pathological disorders comprising neurological disorders, cardiac repair, autoimmune disease, obesity, atherosclerosis, etc. Reactive oxygen species (ROS) produced by the various cell types serve as signaling molecules in several cellular mechanisms and regulate various aspects of growth-factor-mediated responses, including lymphangiogenesis. The ROS, including superoxide anion, hydrogen peroxide, and nitric oxide, play both beneficial and detrimental roles depending upon their levels and cellular microenvironment. Low ROS levels are essential for lymphangiogenesis. On the contrary, oxidative stress due to enhanced ROS generation and/or reduced levels of antioxidants suppresses lymphangiogenesis via promoting lymphatic endothelial cell apoptosis and death. In this review article, we provide an overview of types and sources of ROS, discuss the role of ROS in governing lymphangiogenesis and lymphatic function, and summarize the role of lymphatics in various diseases. |
format | Online Article Text |
id | pubmed-9179518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91795182022-06-10 Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function Singla, Bhupesh Aithabathula, Ravi Varma Kiran, Sonia Kapil, Shweta Kumar, Santosh Singh, Udai P. Cells Review The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles. Recent advances in the molecular mechanisms regulating lymphangiogenesis have opened a new area of research on reparative lymphangiogenesis for the treatment of various pathological disorders comprising neurological disorders, cardiac repair, autoimmune disease, obesity, atherosclerosis, etc. Reactive oxygen species (ROS) produced by the various cell types serve as signaling molecules in several cellular mechanisms and regulate various aspects of growth-factor-mediated responses, including lymphangiogenesis. The ROS, including superoxide anion, hydrogen peroxide, and nitric oxide, play both beneficial and detrimental roles depending upon their levels and cellular microenvironment. Low ROS levels are essential for lymphangiogenesis. On the contrary, oxidative stress due to enhanced ROS generation and/or reduced levels of antioxidants suppresses lymphangiogenesis via promoting lymphatic endothelial cell apoptosis and death. In this review article, we provide an overview of types and sources of ROS, discuss the role of ROS in governing lymphangiogenesis and lymphatic function, and summarize the role of lymphatics in various diseases. MDPI 2022-05-26 /pmc/articles/PMC9179518/ /pubmed/35681445 http://dx.doi.org/10.3390/cells11111750 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Singla, Bhupesh Aithabathula, Ravi Varma Kiran, Sonia Kapil, Shweta Kumar, Santosh Singh, Udai P. Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function |
title | Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function |
title_full | Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function |
title_fullStr | Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function |
title_full_unstemmed | Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function |
title_short | Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function |
title_sort | reactive oxygen species in regulating lymphangiogenesis and lymphatic function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179518/ https://www.ncbi.nlm.nih.gov/pubmed/35681445 http://dx.doi.org/10.3390/cells11111750 |
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