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Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function

The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles. Recent advances in the molecular mechanisms regulating lymphangiogenes...

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Autores principales: Singla, Bhupesh, Aithabathula, Ravi Varma, Kiran, Sonia, Kapil, Shweta, Kumar, Santosh, Singh, Udai P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179518/
https://www.ncbi.nlm.nih.gov/pubmed/35681445
http://dx.doi.org/10.3390/cells11111750
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author Singla, Bhupesh
Aithabathula, Ravi Varma
Kiran, Sonia
Kapil, Shweta
Kumar, Santosh
Singh, Udai P.
author_facet Singla, Bhupesh
Aithabathula, Ravi Varma
Kiran, Sonia
Kapil, Shweta
Kumar, Santosh
Singh, Udai P.
author_sort Singla, Bhupesh
collection PubMed
description The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles. Recent advances in the molecular mechanisms regulating lymphangiogenesis have opened a new area of research on reparative lymphangiogenesis for the treatment of various pathological disorders comprising neurological disorders, cardiac repair, autoimmune disease, obesity, atherosclerosis, etc. Reactive oxygen species (ROS) produced by the various cell types serve as signaling molecules in several cellular mechanisms and regulate various aspects of growth-factor-mediated responses, including lymphangiogenesis. The ROS, including superoxide anion, hydrogen peroxide, and nitric oxide, play both beneficial and detrimental roles depending upon their levels and cellular microenvironment. Low ROS levels are essential for lymphangiogenesis. On the contrary, oxidative stress due to enhanced ROS generation and/or reduced levels of antioxidants suppresses lymphangiogenesis via promoting lymphatic endothelial cell apoptosis and death. In this review article, we provide an overview of types and sources of ROS, discuss the role of ROS in governing lymphangiogenesis and lymphatic function, and summarize the role of lymphatics in various diseases.
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spelling pubmed-91795182022-06-10 Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function Singla, Bhupesh Aithabathula, Ravi Varma Kiran, Sonia Kapil, Shweta Kumar, Santosh Singh, Udai P. Cells Review The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles. Recent advances in the molecular mechanisms regulating lymphangiogenesis have opened a new area of research on reparative lymphangiogenesis for the treatment of various pathological disorders comprising neurological disorders, cardiac repair, autoimmune disease, obesity, atherosclerosis, etc. Reactive oxygen species (ROS) produced by the various cell types serve as signaling molecules in several cellular mechanisms and regulate various aspects of growth-factor-mediated responses, including lymphangiogenesis. The ROS, including superoxide anion, hydrogen peroxide, and nitric oxide, play both beneficial and detrimental roles depending upon their levels and cellular microenvironment. Low ROS levels are essential for lymphangiogenesis. On the contrary, oxidative stress due to enhanced ROS generation and/or reduced levels of antioxidants suppresses lymphangiogenesis via promoting lymphatic endothelial cell apoptosis and death. In this review article, we provide an overview of types and sources of ROS, discuss the role of ROS in governing lymphangiogenesis and lymphatic function, and summarize the role of lymphatics in various diseases. MDPI 2022-05-26 /pmc/articles/PMC9179518/ /pubmed/35681445 http://dx.doi.org/10.3390/cells11111750 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Singla, Bhupesh
Aithabathula, Ravi Varma
Kiran, Sonia
Kapil, Shweta
Kumar, Santosh
Singh, Udai P.
Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function
title Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function
title_full Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function
title_fullStr Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function
title_full_unstemmed Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function
title_short Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function
title_sort reactive oxygen species in regulating lymphangiogenesis and lymphatic function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179518/
https://www.ncbi.nlm.nih.gov/pubmed/35681445
http://dx.doi.org/10.3390/cells11111750
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