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Correlation of Dyslipidemia and Inflammation With Obstructive Sleep Apnea Severity
Introduction: Obstructive sleep apnea (OSA) is a serious condition linked with various metabolic disorders and associated with increased all-cause and cardiovascular mortality. Although the potential mechanisms of pathophysiological processes related to OSA are relatively well known, the data regard...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179947/ https://www.ncbi.nlm.nih.gov/pubmed/35694268 http://dx.doi.org/10.3389/fphar.2022.897279 |
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author | Popadic, Viseslav Brajkovic, Milica Klasnja, Slobodan Milic, Natasa Rajovic, Nina Lisulov, Danica Popovic Divac, Anica Ivankovic, Tatjana Manojlovic, Andrea Nikolic, Novica Memon, Lidija Brankovic, Marija Popovic, Maja Sekulic, Ana Macut, Jelica Bjekic Markovic, Olivera Djurasevic, Sinisa Stojkovic, Maja Todorovic, Zoran Zdravkovic, Marija |
author_facet | Popadic, Viseslav Brajkovic, Milica Klasnja, Slobodan Milic, Natasa Rajovic, Nina Lisulov, Danica Popovic Divac, Anica Ivankovic, Tatjana Manojlovic, Andrea Nikolic, Novica Memon, Lidija Brankovic, Marija Popovic, Maja Sekulic, Ana Macut, Jelica Bjekic Markovic, Olivera Djurasevic, Sinisa Stojkovic, Maja Todorovic, Zoran Zdravkovic, Marija |
author_sort | Popadic, Viseslav |
collection | PubMed |
description | Introduction: Obstructive sleep apnea (OSA) is a serious condition linked with various metabolic disorders and associated with increased all-cause and cardiovascular mortality. Although the potential mechanisms of pathophysiological processes related to OSA are relatively well known, the data regarding the correlation between obstructive sleep apnea, dyslipidemia, and systemic inflammation are still inconclusive. Methods: The study was conducted as a retrospective cohort study including 328 patients with newly diagnosed obstructive sleep apnea during the period between April 2018, and May 2020, in University Clinical Hospital Center “Bezanijska kosa”, Belgrade, Serbia. Polysomnography was performed in all patients according to the protocol. Numerous demographic, antropometric, laboratory, and clinical data were correlated to Apnea-Hypopnea Index (AHI) as a dependent variable, with a particular review on the relation between lipid abnormalities, inflammatory parameters, and obstructive sleep apnea severity. Multivariate logistic regression model was used to assess predictors of severe OSA (AHI ≥30 per hour). Results: A total of 328 patients were included in the study. The mean age of the patients was 54.0 ± 12.5 years and more than two-thirds were male (68.8%). The majority of the patients had an AHI of at least 30 events per hour. Patients with severe OSA were more frequently male, obese, hypertensive and hyperlipidemic, and had increased neck circumference (both male and female patients). One hundred and thirty-two patients had metabolic syndrome. Patients with severe OSA more frequently had metabolic syndrome and significantly higher levels of glucose, creatinine, uric acid, AST, ALT, CK, microalbumine/creatinine ratio, triglyceride, total cholesterol, HDL, total cholеsterol to HDL‐C ratio, CRP, and ESR. In the multivariate linear regression model with AHI (≥30 per hour) as a dependent variable, of demographic and clinical data, triglycerides ≥1.7 mmol/L and CRP >5 mg/L were significantly associated with AHI≥30 per hour. Conclusion: The present study on 328 patients with newly diagnosed obstructive sleep apnea revealed significant relation of lipid abnormalities, inflammatory markers, and other clinically important data with obstructive sleep apnea severity. These results can lead to a better understanding of the underlying pathophysiological processes and open the door to a new world of potentially useful therapeutic modalities. |
format | Online Article Text |
id | pubmed-9179947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91799472022-06-10 Correlation of Dyslipidemia and Inflammation With Obstructive Sleep Apnea Severity Popadic, Viseslav Brajkovic, Milica Klasnja, Slobodan Milic, Natasa Rajovic, Nina Lisulov, Danica Popovic Divac, Anica Ivankovic, Tatjana Manojlovic, Andrea Nikolic, Novica Memon, Lidija Brankovic, Marija Popovic, Maja Sekulic, Ana Macut, Jelica Bjekic Markovic, Olivera Djurasevic, Sinisa Stojkovic, Maja Todorovic, Zoran Zdravkovic, Marija Front Pharmacol Pharmacology Introduction: Obstructive sleep apnea (OSA) is a serious condition linked with various metabolic disorders and associated with increased all-cause and cardiovascular mortality. Although the potential mechanisms of pathophysiological processes related to OSA are relatively well known, the data regarding the correlation between obstructive sleep apnea, dyslipidemia, and systemic inflammation are still inconclusive. Methods: The study was conducted as a retrospective cohort study including 328 patients with newly diagnosed obstructive sleep apnea during the period between April 2018, and May 2020, in University Clinical Hospital Center “Bezanijska kosa”, Belgrade, Serbia. Polysomnography was performed in all patients according to the protocol. Numerous demographic, antropometric, laboratory, and clinical data were correlated to Apnea-Hypopnea Index (AHI) as a dependent variable, with a particular review on the relation between lipid abnormalities, inflammatory parameters, and obstructive sleep apnea severity. Multivariate logistic regression model was used to assess predictors of severe OSA (AHI ≥30 per hour). Results: A total of 328 patients were included in the study. The mean age of the patients was 54.0 ± 12.5 years and more than two-thirds were male (68.8%). The majority of the patients had an AHI of at least 30 events per hour. Patients with severe OSA were more frequently male, obese, hypertensive and hyperlipidemic, and had increased neck circumference (both male and female patients). One hundred and thirty-two patients had metabolic syndrome. Patients with severe OSA more frequently had metabolic syndrome and significantly higher levels of glucose, creatinine, uric acid, AST, ALT, CK, microalbumine/creatinine ratio, triglyceride, total cholesterol, HDL, total cholеsterol to HDL‐C ratio, CRP, and ESR. In the multivariate linear regression model with AHI (≥30 per hour) as a dependent variable, of demographic and clinical data, triglycerides ≥1.7 mmol/L and CRP >5 mg/L were significantly associated with AHI≥30 per hour. Conclusion: The present study on 328 patients with newly diagnosed obstructive sleep apnea revealed significant relation of lipid abnormalities, inflammatory markers, and other clinically important data with obstructive sleep apnea severity. These results can lead to a better understanding of the underlying pathophysiological processes and open the door to a new world of potentially useful therapeutic modalities. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9179947/ /pubmed/35694268 http://dx.doi.org/10.3389/fphar.2022.897279 Text en Copyright © 2022 Popadic, Brajkovic, Klasnja, Milic, Rajovic, Lisulov, Divac, Ivankovic, Manojlovic, Nikolic, Memon, Brankovic, Popovic, Sekulic, Macut, Markovic, Djurasevic, Stojkovic, Todorovic and Zdravkovic. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Popadic, Viseslav Brajkovic, Milica Klasnja, Slobodan Milic, Natasa Rajovic, Nina Lisulov, Danica Popovic Divac, Anica Ivankovic, Tatjana Manojlovic, Andrea Nikolic, Novica Memon, Lidija Brankovic, Marija Popovic, Maja Sekulic, Ana Macut, Jelica Bjekic Markovic, Olivera Djurasevic, Sinisa Stojkovic, Maja Todorovic, Zoran Zdravkovic, Marija Correlation of Dyslipidemia and Inflammation With Obstructive Sleep Apnea Severity |
title | Correlation of Dyslipidemia and Inflammation With Obstructive Sleep Apnea Severity |
title_full | Correlation of Dyslipidemia and Inflammation With Obstructive Sleep Apnea Severity |
title_fullStr | Correlation of Dyslipidemia and Inflammation With Obstructive Sleep Apnea Severity |
title_full_unstemmed | Correlation of Dyslipidemia and Inflammation With Obstructive Sleep Apnea Severity |
title_short | Correlation of Dyslipidemia and Inflammation With Obstructive Sleep Apnea Severity |
title_sort | correlation of dyslipidemia and inflammation with obstructive sleep apnea severity |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179947/ https://www.ncbi.nlm.nih.gov/pubmed/35694268 http://dx.doi.org/10.3389/fphar.2022.897279 |
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