Inhibition of Adipose Tissue Beiging by HIV Integrase Inhibitors, Dolutegravir and Bictegravir, Is Associated with Adipocyte Hypertrophy, Hypoxia, Elevated Fibrosis, and Insulin Resistance in Simian Adipose Tissue and Human Adipocytes

For people living with HIV, treatment with integrase-strand-transfer-inhibitors (INSTIs) can promote adipose tissue (AT) gain. We previously demonstrated that INSTIs can induce hypertrophy and fibrosis in AT of macaques and humans. By promoting energy expenditure, the emergence of beige adipocytes i...

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Detalles Bibliográficos
Autores principales: Ngono Ayissi, Kenza, Gorwood, Jennifer, Le Pelletier, Laura, Bourgeois, Christine, Beaupère, Carine, Auclair, Martine, Foresti, Roberta, Motterlini, Roberto, Atlan, Michael, Barrail-Tran, Aurélie, Le Grand, Roger, Desjardins, Delphine, Fève, Bruno, Lambotte, Olivier, Capeau, Jacqueline, Béréziat, Véronique, Lagathu, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180037/
https://www.ncbi.nlm.nih.gov/pubmed/35681536
http://dx.doi.org/10.3390/cells11111841

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