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Governance of Heritable Human Gene Editing World-Wide and Beyond

To date, the controversy surrounding the unknown risks and consequences of heritable genome editing has grown, with such work raising biosafety and ethical concerns for future generations. However, the current guideline of global governance is limited. In the context of the new framework for the gov...

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Detalles Bibliográficos
Autores principales: Xue, Yang, Shang, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180052/
https://www.ncbi.nlm.nih.gov/pubmed/35682323
http://dx.doi.org/10.3390/ijerph19116739
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author Xue, Yang
Shang, Lijun
author_facet Xue, Yang
Shang, Lijun
author_sort Xue, Yang
collection PubMed
description To date, the controversy surrounding the unknown risks and consequences of heritable genome editing has grown, with such work raising biosafety and ethical concerns for future generations. However, the current guideline of global governance is limited. In the context of the new framework for the governance of human genome editing developed by the World Health Organization (WHO) committee, this paper presents further analysis by highlighting predicaments of governance on germline engineering that merit the most attention: (1) building a scientific culture informed by a broader set of values and considerations in the internal scientific community at large, such as codes of ethics, and education, in addition to awareness-raising measures; and (2) reflecting on and institutionalizing policies in grassroots practice according to local conditions in external governance, such as the experimentalist governance, which is a multi-layered model of governance that establishes an open-ended framework from the top and offers stakeholders the freedom of discussion. The key to achieving these goals is more democratic deliberation between the public and the inclusive engagement of the global scientific community, which has been extensively used in the Biological and Toxin Weapons Convention (BTWC). On a global scale, we believe that practicing heritable human genome editing in accordance with the WHO and BTWC appears to be a good choice.
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spelling pubmed-91800522022-06-10 Governance of Heritable Human Gene Editing World-Wide and Beyond Xue, Yang Shang, Lijun Int J Environ Res Public Health Article To date, the controversy surrounding the unknown risks and consequences of heritable genome editing has grown, with such work raising biosafety and ethical concerns for future generations. However, the current guideline of global governance is limited. In the context of the new framework for the governance of human genome editing developed by the World Health Organization (WHO) committee, this paper presents further analysis by highlighting predicaments of governance on germline engineering that merit the most attention: (1) building a scientific culture informed by a broader set of values and considerations in the internal scientific community at large, such as codes of ethics, and education, in addition to awareness-raising measures; and (2) reflecting on and institutionalizing policies in grassroots practice according to local conditions in external governance, such as the experimentalist governance, which is a multi-layered model of governance that establishes an open-ended framework from the top and offers stakeholders the freedom of discussion. The key to achieving these goals is more democratic deliberation between the public and the inclusive engagement of the global scientific community, which has been extensively used in the Biological and Toxin Weapons Convention (BTWC). On a global scale, we believe that practicing heritable human genome editing in accordance with the WHO and BTWC appears to be a good choice. MDPI 2022-05-31 /pmc/articles/PMC9180052/ /pubmed/35682323 http://dx.doi.org/10.3390/ijerph19116739 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xue, Yang
Shang, Lijun
Governance of Heritable Human Gene Editing World-Wide and Beyond
title Governance of Heritable Human Gene Editing World-Wide and Beyond
title_full Governance of Heritable Human Gene Editing World-Wide and Beyond
title_fullStr Governance of Heritable Human Gene Editing World-Wide and Beyond
title_full_unstemmed Governance of Heritable Human Gene Editing World-Wide and Beyond
title_short Governance of Heritable Human Gene Editing World-Wide and Beyond
title_sort governance of heritable human gene editing world-wide and beyond
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180052/
https://www.ncbi.nlm.nih.gov/pubmed/35682323
http://dx.doi.org/10.3390/ijerph19116739
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