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Optimized Heterologous Expression and Efficient Purification of a New TRAIL-Based Antitumor Fusion Protein SRH–DR5-B with Dual VEGFR2 and DR5 Receptor Specificity

In the last two decades, bifunctional proteins have been created by genetic and protein engineering methods to increase therapeutic effects in various diseases, including cancer. Unlike conventional small molecule or monotargeted drugs, bifunctional proteins have increased biological activity while...

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Detalles Bibliográficos
Autores principales:	Yagolovich, Anne V., Artykov, Artem A., Isakova, Alina A., Vorontsova, Yekaterina V., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P., Gasparian, Marine E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180153/ https://www.ncbi.nlm.nih.gov/pubmed/35682540 http://dx.doi.org/10.3390/ijms23115860

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