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Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland

Purpose: Due to the lack of systematic data on antibiotic sensitivity, the treatment of the highly prevalent and pathogenic Helicobacter pylori (H. pylori) infection still poses a significant problem. Therefore, the aim of our study was to compare the efficacy of the three most commonly used anti-H....

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Autores principales: Wasielica-Berger, Justyna, Gugnacki, Patryk, Mlynarczyk, Maryla, Rogalski, Pawel, Swidnicka-Siergiejko, Agnieszka, Antonowicz, Stefania, Krzyzak, Michalina, Maslach, Dominik, Dabrowski, Andrzej, Daniluk, Jaroslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180243/
https://www.ncbi.nlm.nih.gov/pubmed/35682504
http://dx.doi.org/10.3390/ijerph19116921
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author Wasielica-Berger, Justyna
Gugnacki, Patryk
Mlynarczyk, Maryla
Rogalski, Pawel
Swidnicka-Siergiejko, Agnieszka
Antonowicz, Stefania
Krzyzak, Michalina
Maslach, Dominik
Dabrowski, Andrzej
Daniluk, Jaroslaw
author_facet Wasielica-Berger, Justyna
Gugnacki, Patryk
Mlynarczyk, Maryla
Rogalski, Pawel
Swidnicka-Siergiejko, Agnieszka
Antonowicz, Stefania
Krzyzak, Michalina
Maslach, Dominik
Dabrowski, Andrzej
Daniluk, Jaroslaw
author_sort Wasielica-Berger, Justyna
collection PubMed
description Purpose: Due to the lack of systematic data on antibiotic sensitivity, the treatment of the highly prevalent and pathogenic Helicobacter pylori (H. pylori) infection still poses a significant problem. Therefore, the aim of our study was to compare the efficacy of the three most commonly used anti-H. pylori therapies in northeastern Poland. Patients and Methods: This was a retrospective, single-center study performed on 289 outpatients with an H. pylori infection. Patients received one of the following three treatment regimens: (1) bismuth quadruple therapy (BQT) for 10 days, (2) metronidazole-based triple therapy (M-TT) for 10 or 14 days, and (3) levofloxacin-based triple therapy (L-TT) for 10 or 14 days. Results: BQT, M-TT, and L-TT accounted for 93.2% of prescribed anti-H. pylori therapies. The overall success rate for all treatment regimens was 84.1% (243/289). The effectiveness of first- and second-line therapy was similar and reached 83.8% and 86.2%, respectively. The efficacy of the individual treatment regimens was as follows: (1) BQT—89.4% (84/94), (2) M-TT—80.6% (112/139) and 78.8% (26/33) for 10 and 14 days, respectively, and (3) L-TT—84.6% (11/13) and 100% (10/10) for 10 and 14 days, respectively. The overall duration of treatment and type and dose of proton pump inhibitor (PPI) had no effect on the treatment efficacy. Conclusions: In the northeastern part of Poland, 10-day BQT and 10- or 14-day L-TT are effective treatment regimens for H. pylori eradication and have appear to be superior to M-TT. Practitioners in our clinic followed mostly local anti-H. pylori therapy guidelines.
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spelling pubmed-91802432022-06-10 Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland Wasielica-Berger, Justyna Gugnacki, Patryk Mlynarczyk, Maryla Rogalski, Pawel Swidnicka-Siergiejko, Agnieszka Antonowicz, Stefania Krzyzak, Michalina Maslach, Dominik Dabrowski, Andrzej Daniluk, Jaroslaw Int J Environ Res Public Health Article Purpose: Due to the lack of systematic data on antibiotic sensitivity, the treatment of the highly prevalent and pathogenic Helicobacter pylori (H. pylori) infection still poses a significant problem. Therefore, the aim of our study was to compare the efficacy of the three most commonly used anti-H. pylori therapies in northeastern Poland. Patients and Methods: This was a retrospective, single-center study performed on 289 outpatients with an H. pylori infection. Patients received one of the following three treatment regimens: (1) bismuth quadruple therapy (BQT) for 10 days, (2) metronidazole-based triple therapy (M-TT) for 10 or 14 days, and (3) levofloxacin-based triple therapy (L-TT) for 10 or 14 days. Results: BQT, M-TT, and L-TT accounted for 93.2% of prescribed anti-H. pylori therapies. The overall success rate for all treatment regimens was 84.1% (243/289). The effectiveness of first- and second-line therapy was similar and reached 83.8% and 86.2%, respectively. The efficacy of the individual treatment regimens was as follows: (1) BQT—89.4% (84/94), (2) M-TT—80.6% (112/139) and 78.8% (26/33) for 10 and 14 days, respectively, and (3) L-TT—84.6% (11/13) and 100% (10/10) for 10 and 14 days, respectively. The overall duration of treatment and type and dose of proton pump inhibitor (PPI) had no effect on the treatment efficacy. Conclusions: In the northeastern part of Poland, 10-day BQT and 10- or 14-day L-TT are effective treatment regimens for H. pylori eradication and have appear to be superior to M-TT. Practitioners in our clinic followed mostly local anti-H. pylori therapy guidelines. MDPI 2022-06-06 /pmc/articles/PMC9180243/ /pubmed/35682504 http://dx.doi.org/10.3390/ijerph19116921 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wasielica-Berger, Justyna
Gugnacki, Patryk
Mlynarczyk, Maryla
Rogalski, Pawel
Swidnicka-Siergiejko, Agnieszka
Antonowicz, Stefania
Krzyzak, Michalina
Maslach, Dominik
Dabrowski, Andrzej
Daniluk, Jaroslaw
Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland
title Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland
title_full Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland
title_fullStr Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland
title_full_unstemmed Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland
title_short Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland
title_sort comparative effectiveness of various eradication regimens for helicobacter pylori infection in the northeastern region of poland
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180243/
https://www.ncbi.nlm.nih.gov/pubmed/35682504
http://dx.doi.org/10.3390/ijerph19116921
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