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The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders
Epitranscriptomic modifications can affect every aspect of RNA biology, including stability, transport, splicing, and translation, participate in global intracellular mRNA metabolism, and regulate gene expression and a variety of biological processes. N6-methyladenosine (m6A) as the most prevalent m...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180340/ https://www.ncbi.nlm.nih.gov/pubmed/35682599 http://dx.doi.org/10.3390/ijms23115922 |
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author | Lei, Chunguang Wang, Qingzhong |
author_facet | Lei, Chunguang Wang, Qingzhong |
author_sort | Lei, Chunguang |
collection | PubMed |
description | Epitranscriptomic modifications can affect every aspect of RNA biology, including stability, transport, splicing, and translation, participate in global intracellular mRNA metabolism, and regulate gene expression and a variety of biological processes. N6-methyladenosine (m6A) as the most prevalent modification contributes to normal embryonic brain development and memory formation. However, changes in the level of m6A modification and the expression of its related proteins cause abnormal nervous system functions, including brain tissue development retardation, axon regeneration disorders, memory changes, and neural stem cell renewal and differentiation disorders. Recent studies have revealed that m6A modification and its related proteins play key roles in the development of various neuropsychiatric disorders, such as depression, Alzheimer’s disease, and Parkinson’s disease. In this review, we summarize the research progresses of the m6A modification regulation mechanism in the central nervous system and discuss the effects of gene expression regulation mediated by m6A modification on the biological functions of the neuropsychiatric disorders, thereby providing some insight into new research targets and treatment directions for human diseases. |
format | Online Article Text |
id | pubmed-9180340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91803402022-06-10 The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders Lei, Chunguang Wang, Qingzhong Int J Mol Sci Review Epitranscriptomic modifications can affect every aspect of RNA biology, including stability, transport, splicing, and translation, participate in global intracellular mRNA metabolism, and regulate gene expression and a variety of biological processes. N6-methyladenosine (m6A) as the most prevalent modification contributes to normal embryonic brain development and memory formation. However, changes in the level of m6A modification and the expression of its related proteins cause abnormal nervous system functions, including brain tissue development retardation, axon regeneration disorders, memory changes, and neural stem cell renewal and differentiation disorders. Recent studies have revealed that m6A modification and its related proteins play key roles in the development of various neuropsychiatric disorders, such as depression, Alzheimer’s disease, and Parkinson’s disease. In this review, we summarize the research progresses of the m6A modification regulation mechanism in the central nervous system and discuss the effects of gene expression regulation mediated by m6A modification on the biological functions of the neuropsychiatric disorders, thereby providing some insight into new research targets and treatment directions for human diseases. MDPI 2022-05-25 /pmc/articles/PMC9180340/ /pubmed/35682599 http://dx.doi.org/10.3390/ijms23115922 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lei, Chunguang Wang, Qingzhong The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders |
title | The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders |
title_full | The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders |
title_fullStr | The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders |
title_full_unstemmed | The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders |
title_short | The Progression of N6-methyladenosine Study and Its Role in Neuropsychiatric Disorders |
title_sort | progression of n6-methyladenosine study and its role in neuropsychiatric disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180340/ https://www.ncbi.nlm.nih.gov/pubmed/35682599 http://dx.doi.org/10.3390/ijms23115922 |
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