Cargando…

Distinct Motifs in ATAD5 C-Terminal Domain Modulate PCNA Unloading Process

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that functions in key roles for DNA replication and repair. After the completion of DNA synthesis, PCNA should be unloaded from DNA in a timely way. The ATAD5-RFC-Like Complex (ATAD5-RLC) unloads PCNA from DNA. However, the mechanism of the PC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ryu, Eunjin, Ha, Na Young, Jung, Woojae, Yoo, Juyeong, Myung, Kyungjae, Kang, Sukhyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180478/ https://www.ncbi.nlm.nih.gov/pubmed/35681528 http://dx.doi.org/10.3390/cells11111832

Ejemplares similares

Short-range end resection requires ATAD5-mediated PCNA unloading for faithful homologous recombination
por: Park, Su Hyung, et al.
Publicado: (2023)

ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork
por: Kim, Sangin, et al.
Publicado: (2020)

Is PCNA unloading the central function of the Elg1/ATAD5 replication factor C-like complex?
por: Kubota, Takashi, et al.
Publicado: (2013)

ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin
por: Lee, Kyoo-young, et al.
Publicado: (2013)

ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
por: Park, Su Hyung, et al.
Publicado: (2019)

Timely termination of repair DNA synthesis by ATAD5 is important in oxidative DNA damage-induced single-strand break repair
por: Park, Su Hyung, et al.
Publicado: (2021)

Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
por: Kang, Mi-Sun, et al.
Publicado: (2019)

Control of telomere length in yeast by SUMOylated PCNA and the Elg1 PCNA unloader
por: Singh, Pragyan, et al.
Publicado: (2023)

PCNA Ser46-Leu47 residues are crucial in preserving genomic integrity
por: Kim, Sangin, et al.
Publicado: (2023)

PCNA Loaders and Unloaders—One Ring That Rules Them All
por: Arbel, Matan, et al.
Publicado: (2021)

New histone supply regulates replication fork speed and PCNA unloading
por: Mejlvang, Jakob, et al.
Publicado: (2014)

MutSα maintains the mismatch repair capability by inhibiting PCNA unloading
por: Kawasoe, Yoshitaka, et al.
Publicado: (2016)

Effects of Defective Unloading and Recycling of PCNA Revealed by the Analysis of ELG1 Mutants
por: Itzkovich, Ziv, et al.
Publicado: (2023)

The PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast
por: Tamang, Sanjeeta, et al.
Publicado: (2019)

ATAD5 suppresses centrosome over-duplication by regulating UAF1 and ID1
por: Kim, Seong-jung, et al.
Publicado: (2020)

Characterization of subcellular localization of eukaryotic clamp loader/unloader and its regulatory mechanism
por: Park, Su Hyung, et al.
Publicado: (2021)

Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation
por: Kubota, Takashi, et al.
Publicado: (2015)

The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition
por: Huang, Fu, et al.
Publicado: (2016)

The PCNA interaction motifs revisited: thinking outside the PIP-box
por: Prestel, Andreas, et al.
Publicado: (2019)

Response terminated displays unload selective attention
por: Roper, Zachary J. J., et al.
Publicado: (2013)

Control of Genome Integrity by RFC Complexes; Conductors of PCNA Loading onto and Unloading from Chromatin during DNA Replication
por: Shiomi, Yasushi, et al.
Publicado: (2017)

A structure–function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance
por: Shemesh, Keren, et al.
Publicado: (2017)

The Yeast PCNA Unloader Elg1 RFC-Like Complex Plays a Role in Eliciting the DNA Damage Checkpoint
por: Sau, Soumitra, et al.
Publicado: (2019)

The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase
por: Vijayakumar, Sangeetha, et al.
Publicado: (2007)

Identification of a novel, widespread, and functionally important PCNA-binding motif
por: Gilljam, Karin M., et al.
Publicado: (2009)

Identification of PCNA-interacting protein motifs in human DNA polymerase δ
por: Khandagale, Prashant, et al.
Publicado: (2020)

Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5
por: Bell, Daphne W., et al.
Publicado: (2011)

Blame ATAD5 for factory closures
por: Leslie, Mitch
Publicado: (2013)

Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2
por: Armstrong, Anthony A., et al.
Publicado: (2012)

The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5
por: Miyashita, Ryota, et al.
Publicado: (2023)

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells
por: Hendel, Ayal, et al.
Publicado: (2011)

Fragment-Based Screening of the Bromodomain of ATAD2
por: Harner, Mary J., et al.
Publicado: (2014)

ATPase family AAA domain-containing protein 2 (ATAD2): From an epigenetic modulator to cancer therapeutic target
por: Fu, Jiahui, et al.
Publicado: (2023)

TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
por: Kang, Hyun Je, et al.
Publicado: (2019)

Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression
por: Nguyen, Hai Dang, et al.
Publicado: (2013)

ATAD2 controls chromatin-bound HIRA turnover
por: Wang, Tao, et al.
Publicado: (2021)

Tumor-Promoting ATAD2 and Its Preclinical Challenges
por: Liu, Haicheng, et al.
Publicado: (2022)

Inhibition of DNA replication by an anti-PCNA aptamer/PCNA complex
por: Kowalska, Ewa, et al.
Publicado: (2018)

The DNA replication fork suppresses CMG unloading from chromatin before termination
por: Low, Emily, et al.
Publicado: (2020)

Structure of an archaeal PCNA1–PCNA2–FEN1 complex: elucidating PCNA subunit and client enzyme specificity
por: Doré, Andrew S., et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_ajlvkij2e46calmb31hk0m1r9k