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The Rationale for “Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin” Approach for Cancer Treatment

Cisplatin is one of the most widely used anticancer drugs in the treatment of various types of solid human cancers, as well as germ cell tumors, sarcomas, and lymphomas. Strong evidence from research has demonstrated higher efficacy of a combination of cisplatin and derivatives, together with hypert...

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Autores principales: de Brito, Renan Vieira, Mancini, Marília Wellichan, Palumbo, Marcel das Neves, de Moraes, Luis Henrique Oliveira, Rodrigues, Gerson Jhonatan, Cervantes, Onivaldo, Sercarz, Joel Avram, Paiva, Marcos Bandiera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180481/
https://www.ncbi.nlm.nih.gov/pubmed/35682611
http://dx.doi.org/10.3390/ijms23115934
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author de Brito, Renan Vieira
Mancini, Marília Wellichan
Palumbo, Marcel das Neves
de Moraes, Luis Henrique Oliveira
Rodrigues, Gerson Jhonatan
Cervantes, Onivaldo
Sercarz, Joel Avram
Paiva, Marcos Bandiera
author_facet de Brito, Renan Vieira
Mancini, Marília Wellichan
Palumbo, Marcel das Neves
de Moraes, Luis Henrique Oliveira
Rodrigues, Gerson Jhonatan
Cervantes, Onivaldo
Sercarz, Joel Avram
Paiva, Marcos Bandiera
author_sort de Brito, Renan Vieira
collection PubMed
description Cisplatin is one of the most widely used anticancer drugs in the treatment of various types of solid human cancers, as well as germ cell tumors, sarcomas, and lymphomas. Strong evidence from research has demonstrated higher efficacy of a combination of cisplatin and derivatives, together with hyperthermia and light, in overcoming drug resistance and improving tumoricidal efficacy. It is well known that the antioncogenic potential of CDDP is markedly enhanced by hyperthermia compared to drug treatment alone. However, more recently, accelerators of high energy particles, such as synchrotrons, have been used to produce powerful and monochromatizable radiation to induce an Auger electron cascade in cis-platinum molecules. This is the concept that makes photoactivation of cis-platinum theoretically possible. Both heat and light increase cisplatin anticancer activity via multiple mechanisms, generating DNA lesions by interacting with purine bases in DNA followed by activation of several signal transduction pathways which finally lead to apoptosis. For the past twenty-seven years, our group has developed infrared photo-thermal activation of cisplatin for cancer treatment from bench to bedside. The future development of photoactivatable prodrugs of platinum-based agents injected intratumorally will increase selectivity, lower toxicity and increase efficacy of this important class of antitumor drugs, particularly when treating tumors accessible to laser-based fiber-optic devices, as in head and neck cancer. In this article, the mechanistic rationale of combined intratumor injections of cisplatin and laser-induced thermal therapy (CDDP–LITT) and the clinical application of such minimally invasive treatment for cancer are reviewed.
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spelling pubmed-91804812022-06-10 The Rationale for “Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin” Approach for Cancer Treatment de Brito, Renan Vieira Mancini, Marília Wellichan Palumbo, Marcel das Neves de Moraes, Luis Henrique Oliveira Rodrigues, Gerson Jhonatan Cervantes, Onivaldo Sercarz, Joel Avram Paiva, Marcos Bandiera Int J Mol Sci Review Cisplatin is one of the most widely used anticancer drugs in the treatment of various types of solid human cancers, as well as germ cell tumors, sarcomas, and lymphomas. Strong evidence from research has demonstrated higher efficacy of a combination of cisplatin and derivatives, together with hyperthermia and light, in overcoming drug resistance and improving tumoricidal efficacy. It is well known that the antioncogenic potential of CDDP is markedly enhanced by hyperthermia compared to drug treatment alone. However, more recently, accelerators of high energy particles, such as synchrotrons, have been used to produce powerful and monochromatizable radiation to induce an Auger electron cascade in cis-platinum molecules. This is the concept that makes photoactivation of cis-platinum theoretically possible. Both heat and light increase cisplatin anticancer activity via multiple mechanisms, generating DNA lesions by interacting with purine bases in DNA followed by activation of several signal transduction pathways which finally lead to apoptosis. For the past twenty-seven years, our group has developed infrared photo-thermal activation of cisplatin for cancer treatment from bench to bedside. The future development of photoactivatable prodrugs of platinum-based agents injected intratumorally will increase selectivity, lower toxicity and increase efficacy of this important class of antitumor drugs, particularly when treating tumors accessible to laser-based fiber-optic devices, as in head and neck cancer. In this article, the mechanistic rationale of combined intratumor injections of cisplatin and laser-induced thermal therapy (CDDP–LITT) and the clinical application of such minimally invasive treatment for cancer are reviewed. MDPI 2022-05-25 /pmc/articles/PMC9180481/ /pubmed/35682611 http://dx.doi.org/10.3390/ijms23115934 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
de Brito, Renan Vieira
Mancini, Marília Wellichan
Palumbo, Marcel das Neves
de Moraes, Luis Henrique Oliveira
Rodrigues, Gerson Jhonatan
Cervantes, Onivaldo
Sercarz, Joel Avram
Paiva, Marcos Bandiera
The Rationale for “Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin” Approach for Cancer Treatment
title The Rationale for “Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin” Approach for Cancer Treatment
title_full The Rationale for “Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin” Approach for Cancer Treatment
title_fullStr The Rationale for “Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin” Approach for Cancer Treatment
title_full_unstemmed The Rationale for “Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin” Approach for Cancer Treatment
title_short The Rationale for “Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin” Approach for Cancer Treatment
title_sort rationale for “laser-induced thermal therapy (litt) and intratumoral cisplatin” approach for cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180481/
https://www.ncbi.nlm.nih.gov/pubmed/35682611
http://dx.doi.org/10.3390/ijms23115934
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