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Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics

MicroRNAs (miRNAs) are small non-coding RNAs (18–24 nucleotides) that play significant roles in cell proliferation, development, invasion, cancer development, cancer progression, and anti-cancer drug resistance. miRNAs target multiple genes and play diverse roles. miRNAs can bind to the 3′UTR of tar...

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Detalles Bibliográficos
Autores principales: Jo, Hyein, Shim, Kyeonghee, Jeoung, Dooil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180509/
https://www.ncbi.nlm.nih.gov/pubmed/35682560
http://dx.doi.org/10.3390/ijms23115881
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author Jo, Hyein
Shim, Kyeonghee
Jeoung, Dooil
author_facet Jo, Hyein
Shim, Kyeonghee
Jeoung, Dooil
author_sort Jo, Hyein
collection PubMed
description MicroRNAs (miRNAs) are small non-coding RNAs (18–24 nucleotides) that play significant roles in cell proliferation, development, invasion, cancer development, cancer progression, and anti-cancer drug resistance. miRNAs target multiple genes and play diverse roles. miRNAs can bind to the 3′UTR of target genes and inhibit translation or promote the degradation of target genes. miR-200 family miRNAs mostly act as tumor suppressors and are commonly decreased in cancer. The miR-200 family has been reported as a valuable diagnostic and prognostic marker. This review discusses the clinical value of the miR-200 family, focusing on the role of the miR-200 family in the development of cancer and anti-cancer drug resistance. This review also provides an overview of the factors that regulate the expression of the miR-200 family, targets of miR-200 family miRNAs, and the mechanism of anti-cancer drug resistance regulated by the miR-200 family.
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spelling pubmed-91805092022-06-10 Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics Jo, Hyein Shim, Kyeonghee Jeoung, Dooil Int J Mol Sci Review MicroRNAs (miRNAs) are small non-coding RNAs (18–24 nucleotides) that play significant roles in cell proliferation, development, invasion, cancer development, cancer progression, and anti-cancer drug resistance. miRNAs target multiple genes and play diverse roles. miRNAs can bind to the 3′UTR of target genes and inhibit translation or promote the degradation of target genes. miR-200 family miRNAs mostly act as tumor suppressors and are commonly decreased in cancer. The miR-200 family has been reported as a valuable diagnostic and prognostic marker. This review discusses the clinical value of the miR-200 family, focusing on the role of the miR-200 family in the development of cancer and anti-cancer drug resistance. This review also provides an overview of the factors that regulate the expression of the miR-200 family, targets of miR-200 family miRNAs, and the mechanism of anti-cancer drug resistance regulated by the miR-200 family. MDPI 2022-05-24 /pmc/articles/PMC9180509/ /pubmed/35682560 http://dx.doi.org/10.3390/ijms23115881 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jo, Hyein
Shim, Kyeonghee
Jeoung, Dooil
Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics
title Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics
title_full Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics
title_fullStr Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics
title_full_unstemmed Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics
title_short Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics
title_sort potential of the mir-200 family as a target for developing anti-cancer therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180509/
https://www.ncbi.nlm.nih.gov/pubmed/35682560
http://dx.doi.org/10.3390/ijms23115881
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