Cargando…
Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics
MicroRNAs (miRNAs) are small non-coding RNAs (18–24 nucleotides) that play significant roles in cell proliferation, development, invasion, cancer development, cancer progression, and anti-cancer drug resistance. miRNAs target multiple genes and play diverse roles. miRNAs can bind to the 3′UTR of tar...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180509/ https://www.ncbi.nlm.nih.gov/pubmed/35682560 http://dx.doi.org/10.3390/ijms23115881 |
_version_ | 1784723536634445824 |
---|---|
author | Jo, Hyein Shim, Kyeonghee Jeoung, Dooil |
author_facet | Jo, Hyein Shim, Kyeonghee Jeoung, Dooil |
author_sort | Jo, Hyein |
collection | PubMed |
description | MicroRNAs (miRNAs) are small non-coding RNAs (18–24 nucleotides) that play significant roles in cell proliferation, development, invasion, cancer development, cancer progression, and anti-cancer drug resistance. miRNAs target multiple genes and play diverse roles. miRNAs can bind to the 3′UTR of target genes and inhibit translation or promote the degradation of target genes. miR-200 family miRNAs mostly act as tumor suppressors and are commonly decreased in cancer. The miR-200 family has been reported as a valuable diagnostic and prognostic marker. This review discusses the clinical value of the miR-200 family, focusing on the role of the miR-200 family in the development of cancer and anti-cancer drug resistance. This review also provides an overview of the factors that regulate the expression of the miR-200 family, targets of miR-200 family miRNAs, and the mechanism of anti-cancer drug resistance regulated by the miR-200 family. |
format | Online Article Text |
id | pubmed-9180509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91805092022-06-10 Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics Jo, Hyein Shim, Kyeonghee Jeoung, Dooil Int J Mol Sci Review MicroRNAs (miRNAs) are small non-coding RNAs (18–24 nucleotides) that play significant roles in cell proliferation, development, invasion, cancer development, cancer progression, and anti-cancer drug resistance. miRNAs target multiple genes and play diverse roles. miRNAs can bind to the 3′UTR of target genes and inhibit translation or promote the degradation of target genes. miR-200 family miRNAs mostly act as tumor suppressors and are commonly decreased in cancer. The miR-200 family has been reported as a valuable diagnostic and prognostic marker. This review discusses the clinical value of the miR-200 family, focusing on the role of the miR-200 family in the development of cancer and anti-cancer drug resistance. This review also provides an overview of the factors that regulate the expression of the miR-200 family, targets of miR-200 family miRNAs, and the mechanism of anti-cancer drug resistance regulated by the miR-200 family. MDPI 2022-05-24 /pmc/articles/PMC9180509/ /pubmed/35682560 http://dx.doi.org/10.3390/ijms23115881 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jo, Hyein Shim, Kyeonghee Jeoung, Dooil Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics |
title | Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics |
title_full | Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics |
title_fullStr | Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics |
title_full_unstemmed | Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics |
title_short | Potential of the miR-200 Family as a Target for Developing Anti-Cancer Therapeutics |
title_sort | potential of the mir-200 family as a target for developing anti-cancer therapeutics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180509/ https://www.ncbi.nlm.nih.gov/pubmed/35682560 http://dx.doi.org/10.3390/ijms23115881 |
work_keys_str_mv | AT johyein potentialofthemir200familyasatargetfordevelopinganticancertherapeutics AT shimkyeonghee potentialofthemir200familyasatargetfordevelopinganticancertherapeutics AT jeoungdooil potentialofthemir200familyasatargetfordevelopinganticancertherapeutics |