Could a Lower Toll-like Receptor (TLR) and NF-κB Activation Due to a Changed Charge Distribution in the Spike Protein Be the Reason for the Lower Pathogenicity of Omicron?

The novel SARS-CoV-2 Omicron variant B.1.1.529, which emerged in late 2021, is currently active worldwide, replacing other variants, including the Delta variant, due to an enormously increased infectivity. Multiple substitutions and deletions in the N-terminal domain (NTD) and the receptor binding d...

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Detalles Bibliográficos
Autores principales: Kircheis, Ralf, Planz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180620/
https://www.ncbi.nlm.nih.gov/pubmed/35682644
http://dx.doi.org/10.3390/ijms23115966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180620/
https://www.ncbi.nlm.nih.gov/pubmed/35682644
http://dx.doi.org/10.3390/ijms23115966

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