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Monoubiquitination in Homeostasis and Cancer

Monoubiquitination is a post-translational modification (PTM), through which a single ubiquitin molecule is covalently conjugated to a lysine residue of the target protein. Monoubiquitination regulates the activity, subcellular localization, protein–protein interactions, or endocytosis of the substr...

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Autores principales: Chen, Yujie, Zhou, Dandan, Yao, Yinan, Sun, Yutong, Yao, Fan, Ma, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180643/
https://www.ncbi.nlm.nih.gov/pubmed/35682605
http://dx.doi.org/10.3390/ijms23115925
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author Chen, Yujie
Zhou, Dandan
Yao, Yinan
Sun, Yutong
Yao, Fan
Ma, Li
author_facet Chen, Yujie
Zhou, Dandan
Yao, Yinan
Sun, Yutong
Yao, Fan
Ma, Li
author_sort Chen, Yujie
collection PubMed
description Monoubiquitination is a post-translational modification (PTM), through which a single ubiquitin molecule is covalently conjugated to a lysine residue of the target protein. Monoubiquitination regulates the activity, subcellular localization, protein–protein interactions, or endocytosis of the substrate. In doing so, monoubiquitination is implicated in diverse cellular processes, including gene transcription, endocytosis, signal transduction, cell death, and DNA damage repair, which in turn regulate cell-cycle progression, survival, proliferation, and stress response. In this review, we summarize the functions of monoubiquitination and discuss how this PTM modulates homeostasis and cancer.
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spelling pubmed-91806432022-06-10 Monoubiquitination in Homeostasis and Cancer Chen, Yujie Zhou, Dandan Yao, Yinan Sun, Yutong Yao, Fan Ma, Li Int J Mol Sci Review Monoubiquitination is a post-translational modification (PTM), through which a single ubiquitin molecule is covalently conjugated to a lysine residue of the target protein. Monoubiquitination regulates the activity, subcellular localization, protein–protein interactions, or endocytosis of the substrate. In doing so, monoubiquitination is implicated in diverse cellular processes, including gene transcription, endocytosis, signal transduction, cell death, and DNA damage repair, which in turn regulate cell-cycle progression, survival, proliferation, and stress response. In this review, we summarize the functions of monoubiquitination and discuss how this PTM modulates homeostasis and cancer. MDPI 2022-05-25 /pmc/articles/PMC9180643/ /pubmed/35682605 http://dx.doi.org/10.3390/ijms23115925 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Yujie
Zhou, Dandan
Yao, Yinan
Sun, Yutong
Yao, Fan
Ma, Li
Monoubiquitination in Homeostasis and Cancer
title Monoubiquitination in Homeostasis and Cancer
title_full Monoubiquitination in Homeostasis and Cancer
title_fullStr Monoubiquitination in Homeostasis and Cancer
title_full_unstemmed Monoubiquitination in Homeostasis and Cancer
title_short Monoubiquitination in Homeostasis and Cancer
title_sort monoubiquitination in homeostasis and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180643/
https://www.ncbi.nlm.nih.gov/pubmed/35682605
http://dx.doi.org/10.3390/ijms23115925
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