COX-2 Deficiency Promotes White Adipogenesis via PGE2-Mediated Paracrine Mechanism and Exacerbates Diet-Induced Obesity

Cyclooxygenase-2 (COX-2) plays a critical role in regulating innate immunity and metabolism by producing prostaglandins (PGs) and other lipid mediators. However, the implication of adipose COX-2 in obesity remains largely unknown. Using adipocyte-specific COX-2 knockout (KO) mice, we showed that dep...

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Detalles Bibliográficos
Autores principales: Wang, Chunqing, Zhang, Xing, Luo, Liping, Luo, Yan, Wu, Dandan, Spilca, Dianna, Le, Que, Yang, Xin, Alvarez, Katelyn, Hines, William Curtis, Yang, Xuexian O., Liu, Meilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180646/
https://www.ncbi.nlm.nih.gov/pubmed/35681514
http://dx.doi.org/10.3390/cells11111819

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