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Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models
Nutraceuticals are experiencing a high-rise use nowadays, which is incomparable to a few years ago, due to a shift in consumers’ peculiarity tendencies regarding the selection of alternatives to Western medicine, potential immunity boosters, or gut-health promoters. Nutraceuticals’ compositions and...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180833/ https://www.ncbi.nlm.nih.gov/pubmed/35681386 http://dx.doi.org/10.3390/foods11111636 |
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author | Tihăuan, Bianca-Maria Axinie (Bucos), Mădălina Marinaș, Ioana-Cristina Avram, Ionela Nicoară, Anca-Cecilia Grădișteanu-Pîrcălăbioru, Grațiela Dolete, Georgiana Ivanof, Ana-Maria Onisei, Tatiana Cășărică, Angela Pîrvu, Lucia |
author_facet | Tihăuan, Bianca-Maria Axinie (Bucos), Mădălina Marinaș, Ioana-Cristina Avram, Ionela Nicoară, Anca-Cecilia Grădișteanu-Pîrcălăbioru, Grațiela Dolete, Georgiana Ivanof, Ana-Maria Onisei, Tatiana Cășărică, Angela Pîrvu, Lucia |
author_sort | Tihăuan, Bianca-Maria |
collection | PubMed |
description | Nutraceuticals are experiencing a high-rise use nowadays, which is incomparable to a few years ago, due to a shift in consumers’ peculiarity tendencies regarding the selection of alternatives to Western medicine, potential immunity boosters, or gut-health promoters. Nutraceuticals’ compositions and actual effects should be proportional to their sought-after status, as they are perceived to be the middle ground between pharma rigor and naturally occurring actives. Therefore, the health benefits via nutrition, safe use, and reduction of potential harm should be the main focus for manufacturers. In this light, this study assess the nutritional profile (proteins, fats, fibers, caloric value, minerals) of a novel formulated nutraceutical, its physico-chemical properties, FTIR spectra, antioxidant activity, anthocyanins content, and potential hazards (heavy metals and microbiological contaminants), as well as its cytotoxicity, adherence, and invasion of bacteria on HT-29 cells, as well as its evaluation of beneficial effect, potential prebiotic value, and duplicity effect on gut microbiota in correlation with Regulation (EC) No 1924/2006. The results obtained indicate the growth stimulation of Lb. rhamnosus and the inhibitory effects of E.coli, Ent. Faecalis and Lc. lactis. The interaction between active compounds suggested a modulator effect of the intestinal microbiota by reducing the number of bacteria that adhere to epithelial cells or by inhibiting their growth. |
format | Online Article Text |
id | pubmed-9180833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91808332022-06-10 Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models Tihăuan, Bianca-Maria Axinie (Bucos), Mădălina Marinaș, Ioana-Cristina Avram, Ionela Nicoară, Anca-Cecilia Grădișteanu-Pîrcălăbioru, Grațiela Dolete, Georgiana Ivanof, Ana-Maria Onisei, Tatiana Cășărică, Angela Pîrvu, Lucia Foods Article Nutraceuticals are experiencing a high-rise use nowadays, which is incomparable to a few years ago, due to a shift in consumers’ peculiarity tendencies regarding the selection of alternatives to Western medicine, potential immunity boosters, or gut-health promoters. Nutraceuticals’ compositions and actual effects should be proportional to their sought-after status, as they are perceived to be the middle ground between pharma rigor and naturally occurring actives. Therefore, the health benefits via nutrition, safe use, and reduction of potential harm should be the main focus for manufacturers. In this light, this study assess the nutritional profile (proteins, fats, fibers, caloric value, minerals) of a novel formulated nutraceutical, its physico-chemical properties, FTIR spectra, antioxidant activity, anthocyanins content, and potential hazards (heavy metals and microbiological contaminants), as well as its cytotoxicity, adherence, and invasion of bacteria on HT-29 cells, as well as its evaluation of beneficial effect, potential prebiotic value, and duplicity effect on gut microbiota in correlation with Regulation (EC) No 1924/2006. The results obtained indicate the growth stimulation of Lb. rhamnosus and the inhibitory effects of E.coli, Ent. Faecalis and Lc. lactis. The interaction between active compounds suggested a modulator effect of the intestinal microbiota by reducing the number of bacteria that adhere to epithelial cells or by inhibiting their growth. MDPI 2022-06-01 /pmc/articles/PMC9180833/ /pubmed/35681386 http://dx.doi.org/10.3390/foods11111636 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tihăuan, Bianca-Maria Axinie (Bucos), Mădălina Marinaș, Ioana-Cristina Avram, Ionela Nicoară, Anca-Cecilia Grădișteanu-Pîrcălăbioru, Grațiela Dolete, Georgiana Ivanof, Ana-Maria Onisei, Tatiana Cășărică, Angela Pîrvu, Lucia Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models |
title | Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models |
title_full | Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models |
title_fullStr | Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models |
title_full_unstemmed | Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models |
title_short | Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models |
title_sort | evaluation of the putative duplicity effect of novel nutraceuticals using physico-chemical and biological in vitro models |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180833/ https://www.ncbi.nlm.nih.gov/pubmed/35681386 http://dx.doi.org/10.3390/foods11111636 |
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