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Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models

Nutraceuticals are experiencing a high-rise use nowadays, which is incomparable to a few years ago, due to a shift in consumers’ peculiarity tendencies regarding the selection of alternatives to Western medicine, potential immunity boosters, or gut-health promoters. Nutraceuticals’ compositions and...

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Autores principales: Tihăuan, Bianca-Maria, Axinie (Bucos), Mădălina, Marinaș, Ioana-Cristina, Avram, Ionela, Nicoară, Anca-Cecilia, Grădișteanu-Pîrcălăbioru, Grațiela, Dolete, Georgiana, Ivanof, Ana-Maria, Onisei, Tatiana, Cășărică, Angela, Pîrvu, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180833/
https://www.ncbi.nlm.nih.gov/pubmed/35681386
http://dx.doi.org/10.3390/foods11111636
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author Tihăuan, Bianca-Maria
Axinie (Bucos), Mădălina
Marinaș, Ioana-Cristina
Avram, Ionela
Nicoară, Anca-Cecilia
Grădișteanu-Pîrcălăbioru, Grațiela
Dolete, Georgiana
Ivanof, Ana-Maria
Onisei, Tatiana
Cășărică, Angela
Pîrvu, Lucia
author_facet Tihăuan, Bianca-Maria
Axinie (Bucos), Mădălina
Marinaș, Ioana-Cristina
Avram, Ionela
Nicoară, Anca-Cecilia
Grădișteanu-Pîrcălăbioru, Grațiela
Dolete, Georgiana
Ivanof, Ana-Maria
Onisei, Tatiana
Cășărică, Angela
Pîrvu, Lucia
author_sort Tihăuan, Bianca-Maria
collection PubMed
description Nutraceuticals are experiencing a high-rise use nowadays, which is incomparable to a few years ago, due to a shift in consumers’ peculiarity tendencies regarding the selection of alternatives to Western medicine, potential immunity boosters, or gut-health promoters. Nutraceuticals’ compositions and actual effects should be proportional to their sought-after status, as they are perceived to be the middle ground between pharma rigor and naturally occurring actives. Therefore, the health benefits via nutrition, safe use, and reduction of potential harm should be the main focus for manufacturers. In this light, this study assess the nutritional profile (proteins, fats, fibers, caloric value, minerals) of a novel formulated nutraceutical, its physico-chemical properties, FTIR spectra, antioxidant activity, anthocyanins content, and potential hazards (heavy metals and microbiological contaminants), as well as its cytotoxicity, adherence, and invasion of bacteria on HT-29 cells, as well as its evaluation of beneficial effect, potential prebiotic value, and duplicity effect on gut microbiota in correlation with Regulation (EC) No 1924/2006. The results obtained indicate the growth stimulation of Lb. rhamnosus and the inhibitory effects of E.coli, Ent. Faecalis and Lc. lactis. The interaction between active compounds suggested a modulator effect of the intestinal microbiota by reducing the number of bacteria that adhere to epithelial cells or by inhibiting their growth.
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spelling pubmed-91808332022-06-10 Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models Tihăuan, Bianca-Maria Axinie (Bucos), Mădălina Marinaș, Ioana-Cristina Avram, Ionela Nicoară, Anca-Cecilia Grădișteanu-Pîrcălăbioru, Grațiela Dolete, Georgiana Ivanof, Ana-Maria Onisei, Tatiana Cășărică, Angela Pîrvu, Lucia Foods Article Nutraceuticals are experiencing a high-rise use nowadays, which is incomparable to a few years ago, due to a shift in consumers’ peculiarity tendencies regarding the selection of alternatives to Western medicine, potential immunity boosters, or gut-health promoters. Nutraceuticals’ compositions and actual effects should be proportional to their sought-after status, as they are perceived to be the middle ground between pharma rigor and naturally occurring actives. Therefore, the health benefits via nutrition, safe use, and reduction of potential harm should be the main focus for manufacturers. In this light, this study assess the nutritional profile (proteins, fats, fibers, caloric value, minerals) of a novel formulated nutraceutical, its physico-chemical properties, FTIR spectra, antioxidant activity, anthocyanins content, and potential hazards (heavy metals and microbiological contaminants), as well as its cytotoxicity, adherence, and invasion of bacteria on HT-29 cells, as well as its evaluation of beneficial effect, potential prebiotic value, and duplicity effect on gut microbiota in correlation with Regulation (EC) No 1924/2006. The results obtained indicate the growth stimulation of Lb. rhamnosus and the inhibitory effects of E.coli, Ent. Faecalis and Lc. lactis. The interaction between active compounds suggested a modulator effect of the intestinal microbiota by reducing the number of bacteria that adhere to epithelial cells or by inhibiting their growth. MDPI 2022-06-01 /pmc/articles/PMC9180833/ /pubmed/35681386 http://dx.doi.org/10.3390/foods11111636 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tihăuan, Bianca-Maria
Axinie (Bucos), Mădălina
Marinaș, Ioana-Cristina
Avram, Ionela
Nicoară, Anca-Cecilia
Grădișteanu-Pîrcălăbioru, Grațiela
Dolete, Georgiana
Ivanof, Ana-Maria
Onisei, Tatiana
Cășărică, Angela
Pîrvu, Lucia
Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models
title Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models
title_full Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models
title_fullStr Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models
title_full_unstemmed Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models
title_short Evaluation of the Putative Duplicity Effect of Novel Nutraceuticals Using Physico-Chemical and Biological In Vitro Models
title_sort evaluation of the putative duplicity effect of novel nutraceuticals using physico-chemical and biological in vitro models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180833/
https://www.ncbi.nlm.nih.gov/pubmed/35681386
http://dx.doi.org/10.3390/foods11111636
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