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Structural and Functional Insights into GID/CTLH E3 Ligase Complexes

Multi-subunit E3 ligases facilitate ubiquitin transfer by coordinating various substrate receptor subunits with a single catalytic center. Small molecules inducing targeted protein degradation have exploited such complexes, proving successful as therapeutics against previously undruggable targets. T...

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Detalles Bibliográficos
Autores principales:	Maitland, Matthew E. R., Lajoie, Gilles A., Shaw, Gary S., Schild-Poulter, Caroline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9180843/ https://www.ncbi.nlm.nih.gov/pubmed/35682545 http://dx.doi.org/10.3390/ijms23115863

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