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Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece

Aims/Introduction: Several reports indicate an increasing prevalence of chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM). Hyperglycemia and hypertension are the main risk factors for CKD development and progression. However, despite the achievement of recommended targets for blood glu...

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Autores principales: Migdalis, Ilias N., Ioannidis, Ioannis M., Papanas, Nikolaos, Raptis, Athanasios E., Sotiropoulos, Alexios E., Dimitriadis, George D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181038/
https://www.ncbi.nlm.nih.gov/pubmed/35683611
http://dx.doi.org/10.3390/jcm11113224
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author Migdalis, Ilias N.
Ioannidis, Ioannis M.
Papanas, Nikolaos
Raptis, Athanasios E.
Sotiropoulos, Alexios E.
Dimitriadis, George D.
author_facet Migdalis, Ilias N.
Ioannidis, Ioannis M.
Papanas, Nikolaos
Raptis, Athanasios E.
Sotiropoulos, Alexios E.
Dimitriadis, George D.
author_sort Migdalis, Ilias N.
collection PubMed
description Aims/Introduction: Several reports indicate an increasing prevalence of chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM). Hyperglycemia and hypertension are the main risk factors for CKD development and progression. However, despite the achievement of recommended targets for blood glucose and blood pressure (BP), the residual risk of diabetic chronic kidney disease (DCKD) remains relatively high. The aim of this study is to examine dyslipidemia and other major risk factors to provide support for the prevention and treatment of DCKD. Materials and Methods: Participants are from the Redit-2-Diag study that examines 1759 subjects within a period of 6 months. DCKD severity is staged according to KDIGO criteria. Results: An increase in hemoglobin A(1c) (1 unit) and systolic blood pressure (1 mm Hg) increases the probability of being classified into a higher CKD stage by 14% and 26%, respectively. Moreover, an increase of triglycerides by 88.5 mg/dL increases the risk of classification to a worse CKD stage by 24%. Conclusions: Elevated triglycerides, systolic blood pressure, and poor glycemic control increase the risk of CKD in T2DM and should be addressed in the treatment strategies.
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spelling pubmed-91810382022-06-10 Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece Migdalis, Ilias N. Ioannidis, Ioannis M. Papanas, Nikolaos Raptis, Athanasios E. Sotiropoulos, Alexios E. Dimitriadis, George D. J Clin Med Article Aims/Introduction: Several reports indicate an increasing prevalence of chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM). Hyperglycemia and hypertension are the main risk factors for CKD development and progression. However, despite the achievement of recommended targets for blood glucose and blood pressure (BP), the residual risk of diabetic chronic kidney disease (DCKD) remains relatively high. The aim of this study is to examine dyslipidemia and other major risk factors to provide support for the prevention and treatment of DCKD. Materials and Methods: Participants are from the Redit-2-Diag study that examines 1759 subjects within a period of 6 months. DCKD severity is staged according to KDIGO criteria. Results: An increase in hemoglobin A(1c) (1 unit) and systolic blood pressure (1 mm Hg) increases the probability of being classified into a higher CKD stage by 14% and 26%, respectively. Moreover, an increase of triglycerides by 88.5 mg/dL increases the risk of classification to a worse CKD stage by 24%. Conclusions: Elevated triglycerides, systolic blood pressure, and poor glycemic control increase the risk of CKD in T2DM and should be addressed in the treatment strategies. MDPI 2022-06-06 /pmc/articles/PMC9181038/ /pubmed/35683611 http://dx.doi.org/10.3390/jcm11113224 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Migdalis, Ilias N.
Ioannidis, Ioannis M.
Papanas, Nikolaos
Raptis, Athanasios E.
Sotiropoulos, Alexios E.
Dimitriadis, George D.
Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece
title Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece
title_full Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece
title_fullStr Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece
title_full_unstemmed Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece
title_short Hypertriglyceridemia and Other Risk Factors of Chronic Kidney Disease in Type 2 Diabetes: A Hospital-Based Clinic Population in Greece
title_sort hypertriglyceridemia and other risk factors of chronic kidney disease in type 2 diabetes: a hospital-based clinic population in greece
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181038/
https://www.ncbi.nlm.nih.gov/pubmed/35683611
http://dx.doi.org/10.3390/jcm11113224
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