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Sepsis Related Mortality Associated with an Inflammatory Burst in Patients Admitting to the Department of Internal Medicine with Apparently Normal C-Reactive Protein Concentration
Background: Patients who are admitted to the Department of Internal Medicine with apparently normal C-reactive protein (CRP) concentration impose a special challenge due the assumption that they might not harbor a severe and potentially lethal medical condition. Methods: A retrospective cohort of al...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181046/ https://www.ncbi.nlm.nih.gov/pubmed/35683538 http://dx.doi.org/10.3390/jcm11113151 |
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author | Meilik, Ronnie Ben-Assayag, Hadas Meilik, Ahuva Berliner, Shlomo Zeltser, David Shapira, Itzhak Rogowski, Ori Goldiner, Ilana Shenhar-Tsarfaty, Shani Wasserman, Asaf |
author_facet | Meilik, Ronnie Ben-Assayag, Hadas Meilik, Ahuva Berliner, Shlomo Zeltser, David Shapira, Itzhak Rogowski, Ori Goldiner, Ilana Shenhar-Tsarfaty, Shani Wasserman, Asaf |
author_sort | Meilik, Ronnie |
collection | PubMed |
description | Background: Patients who are admitted to the Department of Internal Medicine with apparently normal C-reactive protein (CRP) concentration impose a special challenge due the assumption that they might not harbor a severe and potentially lethal medical condition. Methods: A retrospective cohort of all patients who were admitted to the Department of Internal Medicine with a CRP concentration of ≤31.9 mg/L and had a second CRP test obtained within the next 24 h. Seven day mortality data were analyzed. Results: Overall, 3504 patients were analyzed with a mean first and second CRP of 8.8 (8.5) and 14.6 (21.6) mg/L, respectively. The seven day mortality increased from 1.8% in the first quartile of the first CRP to 7.5% in the fourth quartile of the first CRP (p < 0.0001) and from 0.6% in the first quartile of the second CRP to 9.5% in the fourth quartile of the second CRP test (p < 0.0001), suggesting a clear relation between the admission CRP and in hospital seven day mortality. Conclusions: An association exists between the quartiles of CRP and 7-day mortality as well as sepsis related cause of death. Furthermore, the CRP values 24 h after hospital admission improved the discrimination. |
format | Online Article Text |
id | pubmed-9181046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91810462022-06-10 Sepsis Related Mortality Associated with an Inflammatory Burst in Patients Admitting to the Department of Internal Medicine with Apparently Normal C-Reactive Protein Concentration Meilik, Ronnie Ben-Assayag, Hadas Meilik, Ahuva Berliner, Shlomo Zeltser, David Shapira, Itzhak Rogowski, Ori Goldiner, Ilana Shenhar-Tsarfaty, Shani Wasserman, Asaf J Clin Med Article Background: Patients who are admitted to the Department of Internal Medicine with apparently normal C-reactive protein (CRP) concentration impose a special challenge due the assumption that they might not harbor a severe and potentially lethal medical condition. Methods: A retrospective cohort of all patients who were admitted to the Department of Internal Medicine with a CRP concentration of ≤31.9 mg/L and had a second CRP test obtained within the next 24 h. Seven day mortality data were analyzed. Results: Overall, 3504 patients were analyzed with a mean first and second CRP of 8.8 (8.5) and 14.6 (21.6) mg/L, respectively. The seven day mortality increased from 1.8% in the first quartile of the first CRP to 7.5% in the fourth quartile of the first CRP (p < 0.0001) and from 0.6% in the first quartile of the second CRP to 9.5% in the fourth quartile of the second CRP test (p < 0.0001), suggesting a clear relation between the admission CRP and in hospital seven day mortality. Conclusions: An association exists between the quartiles of CRP and 7-day mortality as well as sepsis related cause of death. Furthermore, the CRP values 24 h after hospital admission improved the discrimination. MDPI 2022-06-01 /pmc/articles/PMC9181046/ /pubmed/35683538 http://dx.doi.org/10.3390/jcm11113151 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Meilik, Ronnie Ben-Assayag, Hadas Meilik, Ahuva Berliner, Shlomo Zeltser, David Shapira, Itzhak Rogowski, Ori Goldiner, Ilana Shenhar-Tsarfaty, Shani Wasserman, Asaf Sepsis Related Mortality Associated with an Inflammatory Burst in Patients Admitting to the Department of Internal Medicine with Apparently Normal C-Reactive Protein Concentration |
title | Sepsis Related Mortality Associated with an Inflammatory Burst in Patients Admitting to the Department of Internal Medicine with Apparently Normal C-Reactive Protein Concentration |
title_full | Sepsis Related Mortality Associated with an Inflammatory Burst in Patients Admitting to the Department of Internal Medicine with Apparently Normal C-Reactive Protein Concentration |
title_fullStr | Sepsis Related Mortality Associated with an Inflammatory Burst in Patients Admitting to the Department of Internal Medicine with Apparently Normal C-Reactive Protein Concentration |
title_full_unstemmed | Sepsis Related Mortality Associated with an Inflammatory Burst in Patients Admitting to the Department of Internal Medicine with Apparently Normal C-Reactive Protein Concentration |
title_short | Sepsis Related Mortality Associated with an Inflammatory Burst in Patients Admitting to the Department of Internal Medicine with Apparently Normal C-Reactive Protein Concentration |
title_sort | sepsis related mortality associated with an inflammatory burst in patients admitting to the department of internal medicine with apparently normal c-reactive protein concentration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181046/ https://www.ncbi.nlm.nih.gov/pubmed/35683538 http://dx.doi.org/10.3390/jcm11113151 |
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