Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway

Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of...

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Autores principales: Naomi, Ruth, Bahari, Hasnah, Ong, Zhi Yi, Keong, Yong Yoke, Embong, Hashim, Rajandram, Retnagowri, Teoh, Soo Huat, Othman, Fezah, Hasham, Rosnani, Yin, Khoo Boon, Kaniappan, Priyatharisni, Yazid, Muhammad Dain, Zakaria, Zainul Amiruddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181071/
https://www.ncbi.nlm.nih.gov/pubmed/35682652
http://dx.doi.org/10.3390/ijms23115972
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author Naomi, Ruth
Bahari, Hasnah
Ong, Zhi Yi
Keong, Yong Yoke
Embong, Hashim
Rajandram, Retnagowri
Teoh, Soo Huat
Othman, Fezah
Hasham, Rosnani
Yin, Khoo Boon
Kaniappan, Priyatharisni
Yazid, Muhammad Dain
Zakaria, Zainul Amiruddin
author_facet Naomi, Ruth
Bahari, Hasnah
Ong, Zhi Yi
Keong, Yong Yoke
Embong, Hashim
Rajandram, Retnagowri
Teoh, Soo Huat
Othman, Fezah
Hasham, Rosnani
Yin, Khoo Boon
Kaniappan, Priyatharisni
Yazid, Muhammad Dain
Zakaria, Zainul Amiruddin
author_sort Naomi, Ruth
collection PubMed
description Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of pharmacological activities, including anti-cancer properties, particularly in the lipid-dependent cancer pathway. Lipids act as crucial membrane-building elements, fuel for energy-demanding activities, signaling molecules, and regulators of several cellular functions. Studies have shown that alterations in lipid composition assist cancer cells in changing microenvironments. Thus, compounds that target the lipid pathway might serve as potential anti-cancer therapeutic agents. The purpose of this review is to provide an overview of the medicinal chemistry and pharmacology of A. paniculata and its active compounds in terms of anti-cancer activity, primary mechanism of action, and cellular targets, particularly in the lipid-dependent cancer pathway.
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spelling pubmed-91810712022-06-10 Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway Naomi, Ruth Bahari, Hasnah Ong, Zhi Yi Keong, Yong Yoke Embong, Hashim Rajandram, Retnagowri Teoh, Soo Huat Othman, Fezah Hasham, Rosnani Yin, Khoo Boon Kaniappan, Priyatharisni Yazid, Muhammad Dain Zakaria, Zainul Amiruddin Int J Mol Sci Review Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of pharmacological activities, including anti-cancer properties, particularly in the lipid-dependent cancer pathway. Lipids act as crucial membrane-building elements, fuel for energy-demanding activities, signaling molecules, and regulators of several cellular functions. Studies have shown that alterations in lipid composition assist cancer cells in changing microenvironments. Thus, compounds that target the lipid pathway might serve as potential anti-cancer therapeutic agents. The purpose of this review is to provide an overview of the medicinal chemistry and pharmacology of A. paniculata and its active compounds in terms of anti-cancer activity, primary mechanism of action, and cellular targets, particularly in the lipid-dependent cancer pathway. MDPI 2022-05-26 /pmc/articles/PMC9181071/ /pubmed/35682652 http://dx.doi.org/10.3390/ijms23115972 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Naomi, Ruth
Bahari, Hasnah
Ong, Zhi Yi
Keong, Yong Yoke
Embong, Hashim
Rajandram, Retnagowri
Teoh, Soo Huat
Othman, Fezah
Hasham, Rosnani
Yin, Khoo Boon
Kaniappan, Priyatharisni
Yazid, Muhammad Dain
Zakaria, Zainul Amiruddin
Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway
title Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway
title_full Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway
title_fullStr Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway
title_full_unstemmed Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway
title_short Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway
title_sort mechanisms of natural extracts of andrographis paniculata that target lipid-dependent cancer pathways: a view from the signaling pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181071/
https://www.ncbi.nlm.nih.gov/pubmed/35682652
http://dx.doi.org/10.3390/ijms23115972
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