Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway
Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181071/ https://www.ncbi.nlm.nih.gov/pubmed/35682652 http://dx.doi.org/10.3390/ijms23115972 |
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author | Naomi, Ruth Bahari, Hasnah Ong, Zhi Yi Keong, Yong Yoke Embong, Hashim Rajandram, Retnagowri Teoh, Soo Huat Othman, Fezah Hasham, Rosnani Yin, Khoo Boon Kaniappan, Priyatharisni Yazid, Muhammad Dain Zakaria, Zainul Amiruddin |
author_facet | Naomi, Ruth Bahari, Hasnah Ong, Zhi Yi Keong, Yong Yoke Embong, Hashim Rajandram, Retnagowri Teoh, Soo Huat Othman, Fezah Hasham, Rosnani Yin, Khoo Boon Kaniappan, Priyatharisni Yazid, Muhammad Dain Zakaria, Zainul Amiruddin |
author_sort | Naomi, Ruth |
collection | PubMed |
description | Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of pharmacological activities, including anti-cancer properties, particularly in the lipid-dependent cancer pathway. Lipids act as crucial membrane-building elements, fuel for energy-demanding activities, signaling molecules, and regulators of several cellular functions. Studies have shown that alterations in lipid composition assist cancer cells in changing microenvironments. Thus, compounds that target the lipid pathway might serve as potential anti-cancer therapeutic agents. The purpose of this review is to provide an overview of the medicinal chemistry and pharmacology of A. paniculata and its active compounds in terms of anti-cancer activity, primary mechanism of action, and cellular targets, particularly in the lipid-dependent cancer pathway. |
format | Online Article Text |
id | pubmed-9181071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91810712022-06-10 Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway Naomi, Ruth Bahari, Hasnah Ong, Zhi Yi Keong, Yong Yoke Embong, Hashim Rajandram, Retnagowri Teoh, Soo Huat Othman, Fezah Hasham, Rosnani Yin, Khoo Boon Kaniappan, Priyatharisni Yazid, Muhammad Dain Zakaria, Zainul Amiruddin Int J Mol Sci Review Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of pharmacological activities, including anti-cancer properties, particularly in the lipid-dependent cancer pathway. Lipids act as crucial membrane-building elements, fuel for energy-demanding activities, signaling molecules, and regulators of several cellular functions. Studies have shown that alterations in lipid composition assist cancer cells in changing microenvironments. Thus, compounds that target the lipid pathway might serve as potential anti-cancer therapeutic agents. The purpose of this review is to provide an overview of the medicinal chemistry and pharmacology of A. paniculata and its active compounds in terms of anti-cancer activity, primary mechanism of action, and cellular targets, particularly in the lipid-dependent cancer pathway. MDPI 2022-05-26 /pmc/articles/PMC9181071/ /pubmed/35682652 http://dx.doi.org/10.3390/ijms23115972 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Naomi, Ruth Bahari, Hasnah Ong, Zhi Yi Keong, Yong Yoke Embong, Hashim Rajandram, Retnagowri Teoh, Soo Huat Othman, Fezah Hasham, Rosnani Yin, Khoo Boon Kaniappan, Priyatharisni Yazid, Muhammad Dain Zakaria, Zainul Amiruddin Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway |
title | Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway |
title_full | Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway |
title_fullStr | Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway |
title_full_unstemmed | Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway |
title_short | Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway |
title_sort | mechanisms of natural extracts of andrographis paniculata that target lipid-dependent cancer pathways: a view from the signaling pathway |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181071/ https://www.ncbi.nlm.nih.gov/pubmed/35682652 http://dx.doi.org/10.3390/ijms23115972 |
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